Fayard J M, Timouyasse L, Guesnet P, Durand G, Pascal G, Laugier C
Laboratoire de Physiologie Pharmacodynamie, INSERM U 352, INSA Villeurbanne, France.
J Nutr. 1992 Jul;122(7):1529-35. doi: 10.1093/jn/122.7.1529.
Feeding rats a purified diet containing peanut oil with a low alpha-linolenic acid [18:3(n-3)] content resulted in lower amounts of (n-3) polyunsaturated fatty acids, mainly docosahexaenoic acid [22:6(n-3)], greater amounts of docosapentaenoic acid [22:5(n-6)] in uterus phospholipids, and altered postnatal uterus development when compared with rats fed a diet containing peanut and rapeseed oils. Maximal differences in uterine growth, as measured by uterine weight, protein and DNA content, occurred between d 24 and 30 postpartum and disappeared near the end of sexual development (d 40). The induction of the progesterone receptor was not affected, and serum estradiol concentrations were not significantly reduced in deficient animals. Moreover, growth response of the uterus to low doses of 17 beta-estradiol (less than 5 micrograms/kg) was significantly reduced in ovariectomized animals fed the diet containing only peanut oil. However, the maximal response of the uterus, observed with higher 17 beta-estradiol doses (5-50 micrograms/kg), was not affected. Because the two diets used differed in the content of alpha-linolenic acid, it is likely that alpha-linolenic acid deficiency in animals fed the diet containing only peanut oil was the cause of the affected uterine development.
给大鼠喂食含有低α-亚麻酸[18:3(n-3)]含量花生油的纯化日粮，与喂食含有花生油和菜籽油日粮的大鼠相比，其子宫磷脂中(n-3)多不饱和脂肪酸（主要是二十二碳六烯酸[22:6(n-3)]）含量降低，二十二碳五烯酸[22:5(n-6)]含量增加，且产后子宫发育发生改变。通过子宫重量、蛋白质和DNA含量衡量的子宫生长最大差异出现在产后第24天至30天之间，并在性发育接近尾声时（第40天）消失。孕酮受体的诱导未受影响，且缺乏日粮的动物血清雌二醇浓度未显著降低。此外，在喂食仅含花生油日粮的去卵巢动物中，子宫对低剂量17β-雌二醇（小于5微克/千克）的生长反应显著降低。然而，用较高剂量17β-雌二醇（5 - 50微克/千克）观察到的子宫最大反应未受影响。由于所使用的两种日粮在α-亚麻酸含量上存在差异，因此喂食仅含花生油日粮的动物中α-亚麻酸缺乏可能是子宫发育受影响的原因。
