Campbell G L, Reeves W C, Hardy J L, Eldridge B F
Department of Biomedical and Environmental Health Sciences, School of Public Health, University of California, Berkeley 94720.
Am J Epidemiol. 1992 Aug 1;136(3):308-19. doi: 10.1093/oxfordjournals.aje.a116496.
Several human populations in California were surveyed cross-sectionally and longitudinally for neutralizing antibodies to selected arthropod-borne bunyaviruses in the California and Bunyamwera serogroups. Overall, the prevalence of antibodies to California serogroup viruses was 6.4% in 702 individuals sampled during 1963-1988. Comparative antibody titers in individual sera indicated that 4.1% and 1.6% of these infections were caused by viruses similar or identical to Jamestown Canyon and California encephalitis, respectively. Evidence of prior infection with the Jamestown Canyon serotype was found in 10% of 118 humans employed outdoors in high elevation areas and sampled in 1988, including 5 of 16 persons (31%) employed as rangers patrolling in remote forests and meadows. This probably reflects increased exposure to bites of boreal mosquitoes that breed in pools of melted snow. Antibodies to Bunyamwera serogroup viruses, including the Northway serotype, which was recently shown to be enzootic in California, were found in only 2 of 702 humans studied. No seroconversions were detected to selected California or Bunyamwera serogroup viruses in paired samples from 392 humans, including 349 patients with acute central nervous system disease or undifferentiated febrile illnesses who were sampled during 1963-1988, and thus these viruses are currently unconfirmed as human pathogens in California.
对加利福尼亚州的几个人群进行了横断面和纵向调查，以检测其针对加利福尼亚血清群和布尼亚姆韦拉血清群中特定节肢动物传播的布尼亚病毒的中和抗体。总体而言，在1963年至1988年期间采集的702名个体中，针对加利福尼亚血清群病毒的抗体流行率为6.4%。个体血清中的比较抗体滴度表明，这些感染中分别有4.1%和1.6%是由与詹姆斯敦峡谷病毒和加利福尼亚脑炎病毒相似或相同的病毒引起的。在1988年对118名在高海拔地区从事户外工作的人员进行采样时发现，10%的人有感染詹姆斯敦峡谷血清型病毒的既往证据，其中包括16名在偏远森林和草地巡逻的护林员中的5人（31%）。这可能反映出接触在融化雪水形成的水洼中繁殖的北方蚊子叮咬的机会增加。在702名研究对象中，只有2人检测到针对布尼亚姆韦拉血清群病毒的抗体，包括最近在加利福尼亚州发现呈地方流行性的诺斯韦血清型。在392名研究对象的配对样本中，未检测到针对选定的加利福尼亚或布尼亚姆韦拉血清群病毒的血清转化，其中包括1963年至1988年期间采样的349名患有急性中枢神经系统疾病或未分化发热性疾病的患者，因此目前这些病毒在加利福尼亚州尚未被确认为人类病原体。
