Siamopoulos K C, Elisaf M, Antoniadis A, Moutsopoulos H M
Department of Internal Medicine, Medical School, University of Ioannina, Greece.
Am J Nephrol. 1992;12(3):170-3. doi: 10.1159/000168440.
From 1983 to 1990, 32 patients with hemorrhagic fever with renal syndrome (HFRS) were admitted to our hospital. The diagnosis was confirmed by high IgM type titers of antibodies to Hantaan virus. All patients presented with serum and urine abnormalities suggesting renal involvement. Serum creatinine was elevated and ranged between 1.8 and 14.3 mg/dl. Proteinuria ranged between 0.5 and 6.4 g/24 h. Seven patients died due to shock or hemorrhage, while 6 patients were supported by hemodialysis or peritoneal dialysis. Five of them had a complete recovery. Two patients were discharged with some degree of renal impairment which remained stable 12-15 months later. Kidney biopsy in the first patient performed 1 year after his discharge revealed some degree of interstitial fibrosis and tubular atrophy as well as an area with ischemic and sclerosed glomeruli. We conclude that HFRS in Greece is a severe disease with a high mortality rate. The disease may cause chronic renal failure in a limited number of patients.
1983年至1990年期间，我院收治了32例肾综合征出血热（HFRS）患者。汉坦病毒IgM型抗体高滴度确诊了诊断。所有患者均出现提示肾脏受累的血清和尿液异常。血清肌酐升高，范围在1.8至14.3mg/dl之间。蛋白尿范围在0.5至6.4g/24小时之间。7例患者死于休克或出血，6例患者接受血液透析或腹膜透析支持。其中5例完全康复。2例患者出院时存在一定程度的肾功能损害，12至15个月后保持稳定。首例患者出院1年后进行的肾活检显示有一定程度的间质纤维化和肾小管萎缩，以及一个伴有缺血和硬化性肾小球的区域。我们得出结论，希腊的肾综合征出血热是一种严重疾病，死亡率高。该疾病可能在少数患者中导致慢性肾衰竭。
