Grcevska L, Polenaković M, Oncevski A, Zografski D, Gligić A
Department of Nephrology, Institute for Radiology and Oncology, Medical Faculty, Skopje, Yugoslavia.
Clin Nephrol. 1990 Nov;34(5):197-201.
We present two patients with Hantaan virus infection, admitted to the Department of Nephrology, Skopje, at the same time, with the same clinical presentation (chills, fever, abdominal pain, hemorrhages, nausea, headache, proteinuria, hematuria, oliguria, acute renal failure) but with different pathohistological findings and different disease courses. In the first case diffuse proliferative glomerulonephritis was found, with a complete recovery of renal function after a month, with a mild proteinuria and erythruria during the second and the third month. In the second case, glomeruli were normal in general, with slight mesangial proliferation found in two out of twenty, but interstitial edema, lymphocyte infiltrations and tubular changes were noted. Complete recovery was not noted after 3 months of follow-up. The patient is now without hemodialysis treatment, with polyuria, in the stable phase of chronic renal failure which is not improving.
我们报告了两名同时入住斯科普里肾脏病科的汉坦病毒感染患者，他们具有相同的临床表现（寒战、发热、腹痛、出血、恶心、头痛、蛋白尿、血尿、少尿、急性肾衰竭），但病理组织学发现和病程不同。在第一例中，发现弥漫性增殖性肾小球肾炎，一个月后肾功能完全恢复，在第二个月和第三个月期间有轻度蛋白尿和红细胞尿。在第二例中，肾小球总体正常，二十个中有两个出现轻微系膜增殖，但有间质水肿、淋巴细胞浸润和肾小管改变。随访3个月后未发现完全恢复。该患者目前无需血液透析治疗，处于多尿期，慢性肾衰竭稳定但无改善。
