Shen M R, Yang R C, Chen S S
Department of Neurology, Kaohsiung Medical College, Taiwan, Republic of China.
J Pharm Pharmacol. 1992 Jun;44(6):534-6. doi: 10.1111/j.2042-7158.1992.tb03664.x.
Two psychotropic drugs, lithium and haloperidol, were evaluated for their in-vitro effects on sperm motility using a transmembrane migration method. Sperm motility was measured either immediately after semen had been mixed with the drug or after a 2 h incubation period at 37 degrees C. Lithium inhibited human sperm motility in a dose-dependent manner with an EC50 of 10 mM when the semen-lithium mixture had been incubated. Sperm motility was increased to 127% of control when semen had been incubated with 0.027 microM haloperidol; this concentration was within the therapeutic range.
采用跨膜迁移法评估了两种精神药物——锂盐和氟哌啶醇对精子活力的体外作用。在精液与药物混合后立即或在37℃孵育2小时后测量精子活力。当精液-锂盐混合物孵育后，锂盐以剂量依赖性方式抑制人类精子活力，其半数有效浓度（EC50）为10 mM。当精液与0.027 microM氟哌啶醇孵育时，精子活力增加至对照的127%；该浓度在治疗范围内。
