Levin R M, Amsterdam J D, Winokur A, Wein A J
Fertil Steril. 1981 Oct;36(4):503-6.
Imipramine has been shown to have a potent inhibitory effect on sperm motility in vitro. Because of the frequent chronic use of antidepressants in treatment of depression, we investigated the in vivo effects of desmethylimipramine and lithium carbonate on sperm function in patients suffering from clinical depression. We also studied the in vitro effects of a series of neurotrophic agents on sperm motility. There were no significant differences in sperm count, viability, or motility between a group of patients diagnosed as having clinical depression and a group of semen donors with normal sperm characteristics. Three weeks of continuous therapy with desmethylimipramine or lithium carbonate resulted in a significant decrease in sperm viability but no significant change in sperm count or motility. The in vitro drug studies demonstrated that imipramine hydrochloride, desmethylimipramine, chlorpromazine, trifluoperazine, and nortriptyline hydrochloride were all potent inhibitors of sperm motility, whereas lithium carbonate had no effect on motility.
丙咪嗪已被证明在体外对精子活力有强大的抑制作用。由于在抑郁症治疗中频繁长期使用抗抑郁药，我们研究了去甲丙咪嗪和碳酸锂对临床抑郁症患者精子功能的体内影响。我们还研究了一系列神经营养剂对精子活力的体外影响。被诊断患有临床抑郁症的患者组与精子特征正常的精液捐赠者组在精子数量、活力或运动能力方面没有显著差异。连续三周使用去甲丙咪嗪或碳酸锂治疗导致精子活力显著下降，但精子数量或运动能力没有显著变化。体外药物研究表明，盐酸丙咪嗪、去甲丙咪嗪、氯丙嗪、三氟拉嗪和盐酸去甲替林都是精子活力的强效抑制剂，而碳酸锂对运动能力没有影响。
