Raoof N T, Pearson R M, Turner P
Department of Clinical Pharmacology, St Bartholomew's Hospital Medical College, London.
Br J Clin Pharmacol. 1989 Dec;28(6):715-7. doi: 10.1111/j.1365-2125.1989.tb03565.x.
Lithium is a widely prescribed drug used for the treatment of bipolar affective illness. Previous reports on its effects on sperm motility and male fertility are conflicting. The effect of lithium on human sperm motility was examined in vitro using the modified transmembrane migration method. This technique takes account of the dilution of lithium that occurs during the incubation. Lithium inhibits human sperm motility in vitro in concentrations comparable with those reported to be achieved in semen after oral administration.
锂是一种广泛应用于治疗双相情感障碍的处方药。先前关于其对精子活力和男性生育能力影响的报道相互矛盾。采用改良的跨膜迁移方法在体外研究了锂对人类精子活力的影响。该技术考虑到了孵育过程中锂的稀释情况。锂在体外抑制人类精子活力的浓度与口服给药后精液中报道所达到的浓度相当。
