Delventhal S, Brandis A, Ostertag H, Pabst R
Centre of Anatomy, Medical School of Hannover, Federal Republic of Germany.
Virchows Arch B Cell Pathol Incl Mol Pathol. 1992;62(4):271-4. doi: 10.1007/BF02899692.
The relevance of bronchus-associated lymphoid tissue (BALT) in man is still under discussion. Animal experiments indicate that the development of BALT is dependent on microbial stimulation. Therefore, the incidence of BALT was investigated retrospectively in specimens removed during surgical procedures on patients with chronic pulmonary inflammation. All these patients had severe chronic bronchitis and bronchiectasis, but BALT was found in only 8%. In patients with BALT and a malignant tumor, occlusion of a bronchus with poststenotic pneumonia was always present and BALT was observed exclusively in areas peripheral to the occlusion. In man other compartments of the lung must be responsible for the immune function of BALT found in animals.
支气管相关淋巴组织（BALT）在人类中的相关性仍在讨论中。动物实验表明，BALT的发育依赖于微生物刺激。因此，对慢性肺部炎症患者手术过程中切除的标本进行回顾性研究，以调查BALT的发生率。所有这些患者均患有严重的慢性支气管炎和支气管扩张，但仅8%的患者发现有BALT。在患有BALT和恶性肿瘤的患者中，总是存在支气管阻塞伴狭窄后肺炎，且仅在阻塞部位周边区域观察到BALT。在人类中，肺部的其他区域必定承担了动物体内所发现的BALT的免疫功能。
