Chen Y J, Hsu C C
Department of Pediatrics, Medical College, National Cheng Kung University, Tainan, Taiwan, R.O.C.
Dev Med Child Neurol. 1994 Apr;36(4):312-20. doi: 10.1111/j.1469-8749.1994.tb11851.x.
To determine the long-term neurotoxicity of prenatal exposure to polychlorinated biphenyls (PCBs), 54 children--27 'Yu-Cheng' ('oil disease') children and 27 controls--were administered a battery of tests, including the WISC-R, auditory event-related potentials (P300), pattern visual evoked potentials (P-VEPs) and somatosensory evoked potentials (SSEPs). Full-scale IQ scores on the WISC-R were lower for the Yu-Cheng group than for the control group. Mean P300 latencies were significantly longer, and P300 amplitude significantly more reduced, in the Yu-Cheng group than in the control group at Cz and Pz. There were no significant difference in peak latencies and amplitudes between the two groups for P-VEPs and SSEPs. These findings suggest that prenatal exposure to PCBs tends to affect high cortical function rather than the sensory pathway in the developing brain.
为了确定产前接触多氯联苯（PCBs）的长期神经毒性，对54名儿童——27名“油症”儿童和27名对照组儿童——进行了一系列测试，包括韦氏儿童智力量表修订版（WISC-R）、听觉事件相关电位（P300）、图形视觉诱发电位（P-VEPs）和体感诱发电位（SSEPs）。“油症”组的WISC-R全量表智商得分低于对照组。在Cz和Pz处，“油症”组的平均P300潜伏期显著更长，且P300波幅显著降低。两组之间的P-VEPs和SSEPs的峰潜伏期和波幅没有显著差异。这些发现表明，产前接触多氯联苯倾向于影响发育中大脑的高级皮质功能，而非感觉通路。
