Guo Y L, Lambert G H, Hsu C C
Department of Occupational and Environmental Health, National Cheng Kung University Medical College, Tainan, Taiwan.
Environ Health Perspect. 1995 Sep;103 Suppl 6(Suppl 6):117-22. doi: 10.1289/ehp.95103s6117.
This article reviews the findings in children exposed to various levels of polychlorinated biphenyls (PCBs) and related compounds in utero and early postnatally. Yu-Cheng ("oil-disease") mothers were Taiwanese women exposed to PCBs and their heat-degradation products from the ingestion of contaminated rice oil in 1979. Children of these mothers were born growth retarded, with dysmorphic physical findings, and delayed cognitive development compared with unexposed children. In this article, findings in Yu-Cheng children born between 1978 and 1985 are summarized and compared with two other well-documented cohorts of children prenatally exposed to different levels of PCBs. Results of the investigation in Yu-Cheng children will provide important information about the toxicities, health effects, and mechanisms of PCB/PCDF exposure and demonstrate that the developing human is more sensitive than the adult to the toxic effects of these chemicals.
本文综述了子宫内及出生后早期接触不同水平多氯联苯（PCBs）及相关化合物的儿童的研究结果。“油症”母亲是1979年台湾地区因摄入受污染米糠油而接触多氯联苯及其热降解产物的女性。与未接触的儿童相比，这些母亲所生的孩子出生时生长发育迟缓，有身体畸形表现，认知发育延迟。本文总结了1978年至1985年出生的“油症”儿童的研究结果，并与另外两组有充分记录的产前接触不同水平多氯联苯的儿童队列进行了比较。对“油症”儿童的调查结果将提供有关多氯联苯/多氯二苯并呋喃接触的毒性、健康影响及机制的重要信息，并表明发育中的人类比成年人对这些化学物质的毒性作用更敏感。
