Gasic G J, Koch P A, Hsu B, Gasic T B, Niewiarowski S
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1976 Aug 30;86(3):263-77. doi: 10.1007/BF00286945.
Twelve mouse tumors and 29 human malignancies were assayed in vitro for their capacity to aggregate platelets and induce release of radiolabelled serotonin, and for their ability to coagulate blood plasma and digest the fibrin clot. It was discovered that many human and mouse tumors can induce release of radiolabelled serotonin but that the quantitative relationships between this activity of tumors and their capacity to aggregate platelets was variable, permitting tumors to be classified into 3 different types. The procoagulant and fibrinolytic activity was also quite variable. Since no correlation was found between the 4 assayed tumor activities they appear to be independent, separate thrombogenic properties of tumors. Although the information gathered by this study is still fragmentary, some speculations can be made about the role of these activities in treatment of malignant tumors and in determing patterns of body distribution and control of metastases.
对12个小鼠肿瘤和29个人类恶性肿瘤进行了体外检测，以评估它们聚集血小板和诱导放射性标记血清素释放的能力，以及它们使血浆凝固和消化纤维蛋白凝块的能力。研究发现，许多人类和小鼠肿瘤都能诱导放射性标记血清素的释放，但肿瘤的这种活性与其聚集血小板的能力之间的定量关系是可变的，据此可将肿瘤分为3种不同类型。促凝和纤溶活性也有很大差异。由于在检测的4种肿瘤活性之间未发现相关性，它们似乎是肿瘤独立的、不同的促血栓形成特性。尽管本研究收集的信息仍然不完整，但可以对这些活性在恶性肿瘤治疗以及确定体内分布模式和转移控制方面的作用进行一些推测。
