胶原蛋白形成的研究。IV. 维生素C缺乏对皮肤中中性盐可提取胶原蛋白的影响。
Studies on the formation of collagen. IV. Effect of vitamin C deficiency on the neutral salt-extractible collagen of skin.
作者信息
GROSS J
出版信息
J Exp Med. 1959 Jun 1;109(6):557-69. doi: 10.1084/jem.109.6.557.
Abstract
The skin of severely scorbutic guinea pigs which were losing weight contained no detectible neutral salt-extractible collagen. Conditions of growth (weight gain) which actively induced the formation of neutral salt-extractible collagen in the skin of normal guinea pigs failed to do so in the animal with ascorbic acid deficiency. No excess of non-collagenous proline was found in neutral salt extracts of scorbutic skin as compared with normal. Fractionation of these extracts failed to reveal the presence of significant amounts of a soluble component containing unusual proportions of glycine and proline relative to hydroxyproline. It is concluded that deficiency of ascorbic acid either interferes with the synthesis of new collagen in intact skin or causes its destruction and removal as rapidly as it is produced.
摘要
体重减轻的严重坏血病豚鼠的皮肤中，未检测到可被中性盐提取的胶原蛋白。在正常豚鼠皮肤中能积极诱导形成可被中性盐提取的胶原蛋白的生长条件（体重增加），在缺乏抗坏血酸的动物中却无法实现。与正常情况相比，坏血病皮肤的中性盐提取物中未发现过量的非胶原脯氨酸。对这些提取物进行分级分离，未发现存在大量相对于羟脯氨酸而言含有异常比例甘氨酸和脯氨酸的可溶性成分。结论是，抗坏血酸缺乏要么干扰完整皮肤中新胶原蛋白的合成，要么导致其刚产生就迅速被破坏和清除。
相似文献
1
Studies on the formation of collagen. IV. Effect of vitamin C deficiency on the neutral salt-extractible collagen of skin.胶原蛋白形成的研究。IV. 维生素C缺乏对皮肤中中性盐可提取胶原蛋白的影响。
J Exp Med. 1959 Jun 1;109(6):557-69. doi: 10.1084/jem.109.6.557.
2
Studies in vivo on the biosynthesis of collagen and elastin in ascorbic acid-deficient guinea pigs.关于抗坏血酸缺乏的豚鼠体内胶原蛋白和弹性蛋白生物合成的研究。
Biochem J. 1969 Jun;113(2):387-97. doi: 10.1042/bj1130387.
3
Studies in vivo on the biosynthesis of collagen and elastin in ascorbic acid-deficient guinea pigs. Evidence for the formation and degradation of a partially hydroxylated collagen.抗坏血酸缺乏豚鼠体内胶原蛋白和弹性蛋白生物合成的研究。关于部分羟基化胶原蛋白形成和降解的证据。
Biochem J. 1970 Sep;119(3):575-85. doi: 10.1042/bj1190575.
4
Specifically decreased collagen biosynthesis in scurvy dissociated from an effect on proline hydroxylation and correlated with body weight loss. In vitro studies in guinea pig calvarial bones.坏血病中胶原蛋白生物合成的特异性降低与脯氨酸羟化作用无关，而是与体重减轻相关。豚鼠颅骨的体外研究。
J Clin Invest. 1983 Sep;72(3):826-35. doi: 10.1172/JCI111053.
5
Coordinate regulation of collagen and proteoglycan synthesis in costal cartilage of scorbutic and acutely fasted, vitamin C-supplemented guinea pigs.坏血病、急性禁食及补充维生素C的豚鼠肋软骨中胶原蛋白和蛋白聚糖合成的协同调节
Arch Biochem Biophys. 1986 Apr;246(1):42-51. doi: 10.1016/0003-9861(86)90447-9.
6
Influence of ascorbic acid on ribosomal patterns and collagen biosynthesis in healing wounds of scorbutic guinea pigs.抗坏血酸对坏血病豚鼠愈合伤口中核糖体模式和胶原蛋白生物合成的影响。
Biochem J. 1974 Sep;142(3):641-51. doi: 10.1042/bj1420641.
7
Vitamin C deficiency in guinea pigs differentially affects the expression of type IV collagen, laminin, and elastin in blood vessels.豚鼠体内维生素C缺乏会对血管中IV型胶原蛋白、层粘连蛋白和弹性蛋白的表达产生不同影响。
J Nutr. 1999 Jan;129(1):83-91. doi: 10.1093/jn/129.1.83.
8
Wound healing and collagen formation. III. A quantitative radioautographic study of the utilization of proline-H3 in wounds from normal and scorbutic guinea pigs.伤口愈合与胶原蛋白形成。III. 对正常和坏血病豚鼠伤口中脯氨酸-H3利用情况的定量放射自显影研究。
J Cell Biol. 1962 Oct;15(1):99-108. doi: 10.1083/jcb.15.1.99.
9
10
Regulation of collagen synthesis and mRNA levels in articular cartilage of scorbutic guinea pigs.坏血病豚鼠关节软骨中胶原蛋白合成及mRNA水平的调节
Arch Biochem Biophys. 1986 Apr;246(1):33-41. doi: 10.1016/0003-9861(86)90446-7.
引用本文的文献
1
Antioxidant, Anti-Obesity, Nutritional and Other Beneficial Effects of Different Chili Pepper: A Review.不同辣椒的抗氧化、抗肥胖、营养和其他有益作用：综述。
Molecules. 2022 Jan 28;27(3):898. doi: 10.3390/molecules27030898.
2
Wound healing and collagen formation. II. Fine structure in experimental scurvy.伤口愈合与胶原蛋白形成。II. 实验性坏血病中的精细结构
J Cell Biol. 1962 Mar;12(3):533-51. doi: 10.1083/jcb.12.3.533.
3
WOUND HEALING AND COLLAGEN FORMATION. IV. DISTORTION OF RIBOSOMAL PATTERNS OF FIBROBLASTS IN SCURVY.伤口愈合与胶原蛋白形成。IV. 坏血病中成纤维细胞核糖体模式的畸变。
J Cell Biol. 1964 Aug;22(2):365-89. doi: 10.1083/jcb.22.2.365.
4
METABOLISM OF COLLAGEN IN MAMMALIAN TISSUES.哺乳动物组织中胶原蛋白的代谢
Biophys J. 1964 Jan;4(1 Pt 2):SUPPL93-114. doi: 10.1016/s0006-3495(64)86930-7.
5
Specifically decreased collagen biosynthesis in scurvy dissociated from an effect on proline hydroxylation and correlated with body weight loss. In vitro studies in guinea pig calvarial bones.坏血病中胶原蛋白生物合成的特异性降低与脯氨酸羟化作用无关，而是与体重减轻相关。豚鼠颅骨的体外研究。
J Clin Invest. 1983 Sep;72(3):826-35. doi: 10.1172/JCI111053.
6
Ascorbic acid and aging in the rat. Uptake of ascorbic acid by skin and bone marrow, and its concentration in various organs.抗坏血酸与大鼠衰老。皮肤和骨髓对抗坏血酸的摄取及其在各器官中的浓度。
Biochem J. 1964 Mar;90(3):637-40. doi: 10.1042/bj0900637.
7
Studies in vivo on the biosynthesis of collagen and elastin in ascorbic acid-deficient guinea pigs. Evidence for the formation and degradation of a partially hydroxylated collagen.抗坏血酸缺乏豚鼠体内胶原蛋白和弹性蛋白生物合成的研究。关于部分羟基化胶原蛋白形成和降解的证据。
Biochem J. 1970 Sep;119(3):575-85. doi: 10.1042/bj1190575.
8
Studies in vivo on the biosynthesis of collagen and elastin in ascorbic acid-deficient guinea pigs.关于抗坏血酸缺乏的豚鼠体内胶原蛋白和弹性蛋白生物合成的研究。
Biochem J. 1969 Jun;113(2):387-97. doi: 10.1042/bj1130387.
9
The effect of scurvy on glycosaminoglycans of granulation tissue and costal cartilage.坏血病对肉芽组织和肋软骨中糖胺聚糖的影响。
Biochem J. 1968 Dec;110(4):609-16. doi: 10.1042/bj1100609b.
本文引用的文献
1
2
The determination of hydroxyproline.羟脯氨酸的测定
J Biol Chem. 1950 May;184(1):299-306.
3
Histologic bioassay of 3-methyl-L-ascorbic acid.3-甲基-L-抗坏血酸的组织学生物测定
J Nutr. 1951 Feb;43(2):193-200. doi: 10.1093/jn/43.2.193.
4
[Studies on the formation of collagen. III. Time-dependent solubility changes of collagen in vitro].[胶原蛋白形成的研究。III. 胶原蛋白在体外随时间的溶解度变化]
J Exp Med. 1958 Aug 1;108(2):215-26. doi: 10.1084/jem.108.2.215.
5
Studies on the formation of collagen. II. The influence of growth rate on neutral salt extracts of guinea pig dermis.胶原蛋白形成的研究。II. 生长速率对豚鼠真皮中性盐提取物的影响。
J Exp Med. 1958 Feb 1;107(2):265-77. doi: 10.1084/jem.107.2.265.
6
Studies on the formation of collagen. I. Properties and fractionation of neutral salt extracts of normal guinea pig connective tissue.胶原蛋白形成的研究。I. 正常豚鼠结缔组织中性盐提取物的性质与分级分离
J Exp Med. 1958 Feb 1;107(2):247-63. doi: 10.1084/jem.107.2.247.
7
8
Connective tissue growth stimulated by carrageenin. I. The formation and removal of collagen.角叉菜胶刺激结缔组织生长。I. 胶原蛋白的形成与清除。
Biochem J. 1957 Feb;65(2):277-84. doi: 10.1042/bj0650277.
9
A photometric method for the determination of proline.一种测定脯氨酸的光度法。
J Biol Chem. 1955 Aug;215(2):655-60.
10
The metabolism of collagen and other proteins of the skin of rabbits.兔子皮肤中胶原蛋白及其他蛋白质的新陈代谢
Biochem J. 1954 Apr;56(4):558-69. doi: 10.1042/bj0560558.
Zotero 插件