Pollock T W, Goodwin C W, Schumate G R, Rosato E F
Am J Surg. 1977 Jan;133(1):95-8. doi: 10.1016/0002-9610(77)90200-8.
Interdigestive gastirc acid output and acid secretory response to histamine, insulin and pentagastrin were studied in five dogs before and after creation of a right to left extracardiac vascular shunt. The arterial PO2 decreased from 81.5 +/- 5.5 mm Hg to 39.8 +/- 6.0 mm Hg postoperatively with no change in arterial pH or PaCO2. Basal (interdigestive) acid output increased from 1.19 +/- 0.26 mEq/hr to 4.97 +/- 0.81 mEq/hr postoperatively. Acid secretory response to insulin was increased after the induction of chronic hypoxia. Increased sensitivity to pentagastric was also observed although parietal cell mass (maximum histamine-stimulated output) was unchanged postoperatively. Changes in acid secretory response and PaO2 were present at one week and were sustained through twelve weeks after shunting. Chronic hypoxia resulted in gastric acid hypersecretion secondary to enhanced sensitivity of the parietal cell to a combination of neural and humoral stimuli.
在五只犬建立心外右向左血管分流术前和术后，研究了消化间期胃酸分泌量以及对组胺、胰岛素和五肽胃泌素的酸分泌反应。术后动脉血氧分压从81.5±5.5 mmHg降至39.8±6.0 mmHg，动脉血pH值和二氧化碳分压无变化。基础（消化间期）胃酸分泌量术后从1.19±0.26 mEq/小时增加到4.97±0.81 mEq/小时。慢性缺氧诱导后，对胰岛素的酸分泌反应增强。尽管术后壁细胞量（最大组胺刺激分泌量）未改变，但对五肽胃泌素的敏感性也增加。分流术后一周出现酸分泌反应和动脉血氧分压的变化，并持续至十二周。慢性缺氧导致壁细胞对神经和体液刺激组合的敏感性增强，继而引起胃酸分泌过多。
