The effect of Pluronic F-68 on hybridoma cells in continuous culture.
作者信息
al-Rubeai M, Emery A N, Chalder S
机构信息
Centre for Biochemical Engineering, School of Chemical Engineering, University of Birmingham, UK.
出版信息
Appl Microbiol Biotechnol. 1992 Apr;37(1):44-5. doi: 10.1007/BF00174201.
PMID:1368501
Abstract
The comparative effects of Pluronic on cell growth of hybridomas were studied. The addition of 0.05% Pluronic decreased the steady-state cell number in continuous culture by about 12% compared to a non-supplemented culture. In short-term experiments, results demonstrated a gradual decrease in cell number with increasing concentration of Pluronic. Such growth inhibition was found to be a result of lowering the rate of DNA synthesis.
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