Kondo H, Oritani T, Yamashita K
Department of Agricultural Chemistry, Tohoku University, Sendai, Japan.
Agric Biol Chem. 1990 Jun;54(6):1531-6.
(+/-)-Streptovitacin A (1) and its stereoisomers were synthesized by an aldol reaction of (+/-)-2,4-dimethyl-4-trimethylsiloxy-1-cyclohexanones (4b and 9) with 4-(2-oxoethyl)-2,6-piperidinedione (5). E-72 (2) was derived from synthetic 1. (+/-)-1 showed moderate growth inhibition against fungi and lettuce seeds.
（±）-链黑菌素A（1）及其立体异构体通过（±）-2,4-二甲基-4-三甲基硅氧基-1-环己酮（4b和9）与4-（2-氧代乙基）-2,6-哌啶二酮（5）的羟醛缩合反应合成。E-72（2）由合成的1衍生而来。（±）-1对真菌和生菜种子显示出中等程度的生长抑制作用。
