二氢阿魏酸烷基酯类似物的杀菌活性

Fungicidal activities of dihydroferulic acid alkyl ester analogues.

作者信息

Beck John J, Kim Jong H, Campbell Bruce C, Chou Shen-Chieh

机构信息

Plant Mycotoxin Research Unit, Western Regional Research Center, USDA-ARS, 800 Buchanan Street, Albany, California 94710, USA.

出版信息

J Nat Prod. 2007 May;70(5):779-82. doi: 10.1021/np0606345. Epub 2007 May 1.

DOI:10.1021/np0606345

PMID:17469871

Abstract

The natural product dihydroferulic acid (DFA, 1) and the synthesized DFA methyl (4a), ethyl (4b), propyl (4c), hexyl (4d), octyl (4e), and decyl (4f) esters were examined for antifungal activity. Test fungi included Saccharomyces cerevisiae (wild type, and deletion mutants slt2 Delta and bck1 Delta), Aspergillus fumigatus, and A. flavus. Growth inhibition of S. cerevisiae treated with 5 mM DFA or the corresponding esters was 4a, 4b, and 4c >98%; 4d 18.8%; 1 6.4%; 4e 6.2%; and 4f 2.8%, relative to the control. The 50% minimum inhibitory concentrations for the more active propyl, methyl, and ethyl esters were 1.5, 2.1, and 4.0 mM, respectively. Compound 4c inhibited 100% growth of both aspergilli at 6.4 mM.

摘要

对天然产物二氢阿魏酸（DFA，1）以及合成的DFA甲酯（4a）、乙酯（4b）、丙酯（4c）、己酯（4d）、辛酯（4e）和癸酯（4f）进行了抗真菌活性检测。受试真菌包括酿酒酵母（野生型以及缺失突变体slt2Δ和bck1Δ）、烟曲霉和黄曲霉。与对照相比，用5 mM DFA或相应酯处理的酿酒酵母的生长抑制率为：4a、4b和4c>98%；4d为18.8%；1为6.4%；4e为6.2%；4f为2.8%。活性较高的丙酯、甲酯和乙酯的50%最小抑菌浓度分别为1.5 mM、2.1 mM和4.0 mM。化合物4c在6.4 mM时对两种曲霉菌的生长抑制率均为100%。