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新型抗生素呋喃喹诺菌素A和B。分类学、发酵、分离以及理化和生物学特性。

Novel antibiotics, furaquinocins A and B. Taxonomy, fermentation, isolation and physico-chemical and biological characteristics.

作者信息

Komiyama K, Funayama S, Anraku Y, Ishibashi M, Takahashi Y, Omura S

机构信息

Kitasato Institute, Tokyo, Japan.

出版信息

J Antibiot (Tokyo). 1990 Mar;43(3):247-52. doi: 10.7164/antibiotics.43.247.

DOI:10.7164/antibiotics.43.247
PMID:2324009
Abstract

Two novel antibiotics, furaquinocins A and B were isolated from the culture broth of Streptomyces sp. KO-3988. These antibiotics possess cytocidal activities against HeLa S3 cells in vitro at concentrations of 3.1 micrograms/ml for A and 1.6 micrograms/ml for B. Neither substance possessed antimicrobial activities against Gram-positive and Gram-negative bacteria, fungi or yeast at a concentration of 1,000 micrograms/ml.

摘要

从链霉菌属KO-3988的培养液中分离出两种新型抗生素，呋喃喹诺菌素A和B。这些抗生素在体外对HeLa S3细胞具有杀细胞活性，A的浓度为3.1微克/毫升，B的浓度为1.6微克/毫升。在1000微克/毫升的浓度下，这两种物质对革兰氏阳性菌、革兰氏阴性菌、真菌或酵母均无抗菌活性。

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