COLLINS R E
Science. 1961 May 19;133(3464):1593-4. doi: 10.1126/science.133.3464.1593.
A mathematical theory is developed to explain the observed enhancement of oxygen transport through solutions by hemoglobin. At high partial pressures of oxygen, ordinary diffusion through the solvent accounts for all transport of oxygen, but at low partial pressures the transport may be increased many fold by the presence of hemoglobin. This phenomenon is explained and the possible role of this phenomenon in living organisms is discussed. The theory also indicates a new method of determining dissociation curves from diffusion experiments.
本文提出了一种数学理论,以解释观察到的血红蛋白对溶液中氧气传输的增强作用。在高氧分压下,通过溶剂的普通扩散解释了所有的氧气传输,但在低氧分压下,血红蛋白的存在可使传输增加许多倍。本文对这一现象进行了解释,并讨论了该现象在生物体内可能发挥的作用。该理论还指出了一种从扩散实验中确定解离曲线的新方法。