• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一种针对人类免疫缺陷病毒1型p24保守表位的CD4+细胞毒性T淋巴细胞克隆：细胞毒性活性以及白细胞介素-2和白细胞介素-6的分泌

A CD4+ cytotoxic T-lymphocyte clone to a conserved epitope on human immunodeficiency virus type 1 p24: cytotoxic activity and secretion of interleukin-2 and interleukin-6.

作者信息

Littaua R A, Oldstone M B, Takeda A, Ennis F A

机构信息

Department of Medicine, University of Massachusetts Medical Center, Worcester 01655.

出版信息

J Virol. 1992 Jan;66(1):608-11. doi: 10.1128/JVI.66.1.608-611.1992.

DOI:10.1128/JVI.66.1.608-611.1992
PMID:1370094
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC238325/
Abstract

A CD4+ cytotoxic T-lymphocyte (CTL) clone, established from the peripheral blood of a human immunodeficiency virus (HIV)-seropositive donor, lysed autologous target cells that were infected with a recombinant vaccinia virus containing the gag gene of HIV type 1 and target cells pulsed with p24gag construct expressed in Escherichia coli. The recognition of the HLA-DQ-restricted epitope by this clone was further defined by using overlapping synthetic peptides. The epitope recognized by this CD4+ CTL clone (amino acids 140 to 148) overlaps with a CD8+ epitope and is highly conserved among all isolates of HIV type 1 that have been sequenced. Production and secretion of lymphokines such as interleukin-2 and interleukin-6 after specific antigenic stimulation were demonstrated by this gag-specific CD4+ CTL clone.

摘要

从一名人类免疫缺陷病毒（HIV）血清反应阳性供体的外周血中建立的一个CD4 + 细胞毒性T淋巴细胞（CTL）克隆，裂解了被含有1型HIV gag基因的重组痘苗病毒感染的自体靶细胞，以及用在大肠杆菌中表达的p24gag构建体脉冲处理过的靶细胞。通过使用重叠合成肽进一步确定了该克隆对HLA - DQ限制表位的识别。这个CD4 + CTL克隆识别的表位（氨基酸140至148）与一个CD8 + 表位重叠，并且在所有已测序的1型HIV分离株中高度保守。这个gag特异性CD4 + CTL克隆证明了在特异性抗原刺激后白细胞介素 - 2和白细胞介素 - 6等淋巴因子的产生和分泌。

相似文献

1
A CD4+ cytotoxic T-lymphocyte clone to a conserved epitope on human immunodeficiency virus type 1 p24: cytotoxic activity and secretion of interleukin-2 and interleukin-6.一种针对人类免疫缺陷病毒1型p24保守表位的CD4+细胞毒性T淋巴细胞克隆：细胞毒性活性以及白细胞介素-2和白细胞介素-6的分泌
J Virol. 1992 Jan;66(1):608-11. doi: 10.1128/JVI.66.1.608-611.1992.
2
An HLA-C-restricted CD8+ cytotoxic T-lymphocyte clone recognizes a highly conserved epitope on human immunodeficiency virus type 1 gag.一个HLA - C限制性CD8 + 细胞毒性T淋巴细胞克隆识别1型人类免疫缺陷病毒gag上的一个高度保守表位。
J Virol. 1991 Aug;65(8):4051-6. doi: 10.1128/JVI.65.8.4051-4056.1991.
3
Gag-specific cytotoxic T lymphocytes from human immunodeficiency virus type 1-infected individuals: Gag epitopes are clustered in three regions of the p24gag protein.来自1型人类免疫缺陷病毒感染个体的Gag特异性细胞毒性T淋巴细胞：Gag表位聚集在p24gag蛋白的三个区域。
J Virol. 1993 Feb;67(2):694-702. doi: 10.1128/JVI.67.2.694-702.1993.
4
Definition of two new epitopes on human immunodeficiency virus type 1 gag protein recognized by human CD8+ cytotoxic T lymphocyte clones.
J Clin Virol. 2003 May;27(1):38-43. doi: 10.1016/s1386-6532(02)00109-9.
5
Efficient lysis of human immunodeficiency virus type 1-infected cells by cytotoxic T lymphocytes.细胞毒性T淋巴细胞对1型人类免疫缺陷病毒感染细胞的高效裂解作用。
J Virol. 1996 Sep;70(9):5799-806. doi: 10.1128/JVI.70.9.5799-5806.1996.
6
Recognition of a highly conserved region of human immunodeficiency virus type 1 gp120 by an HLA-Cw4-restricted cytotoxic T-lymphocyte clone.一个HLA-Cw4限制性细胞毒性T淋巴细胞克隆对人类免疫缺陷病毒1型gp120高度保守区域的识别。
J Virol. 1993 Jan;67(1):438-45. doi: 10.1128/JVI.67.1.438-445.1993.
7
Identification of two epitopes on the dengue 4 virus capsid protein recognized by a serotype-specific and a panel of serotype-cross-reactive human CD4+ cytotoxic T-lymphocyte clones.登革4型病毒衣壳蛋白上两个表位的鉴定，这两个表位可被血清型特异性及一组血清型交叉反应性人类CD4+细胞毒性T淋巴细胞克隆识别。
J Virol. 1996 Jan;70(1):141-7. doi: 10.1128/JVI.70.1.141-147.1996.
8
Effective lysis of HIV-1-infected primary CD4+ T cells by a cytotoxic T-lymphocyte clone directed against a novel A2-restricted reverse-transcriptase epitope.
J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Oct 1;19(2):111-20. doi: 10.1097/00042560-199810010-00002.
9
Fine-specificity of cytotoxic T lymphocytes which recognize conserved epitopes of the Gag protein of human immunodeficiency virus type 1.识别1型人类免疫缺陷病毒Gag蛋白保守表位的细胞毒性T淋巴细胞的精细特异性。
J Gen Virol. 1996 Aug;77 ( Pt 8):1659-65. doi: 10.1099/0022-1317-77-8-1659.
10
Dual function of a human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte clone: inhibition of HIV replication by noncytolytic mechanisms and lysis of HIV-infected CD4+ cells.一种人类免疫缺陷病毒（HIV）特异性细胞毒性T淋巴细胞克隆的双重功能：通过非细胞溶解机制抑制HIV复制以及裂解HIV感染的CD4+细胞。
Virology. 1996 Nov 1;225(1):248-53. doi: 10.1006/viro.1996.0597.

引用本文的文献

1
Hepatitis C virus-specific cellular immune responses in individuals with no evidence of infection.无感染证据个体中的丙型肝炎病毒特异性细胞免疫应答。
Virol J. 2012 Mar 28;9:76. doi: 10.1186/1743-422X-9-76.
2
Distinct roles of CD4+ T cell subpopulations in retroviral immunity: lessons from the Friend virus mouse model.CD4+ T 细胞亚群在逆转录病毒免疫中的不同作用：来自 Friend 病毒小鼠模型的启示。
Retrovirology. 2011 Sep 26;8:76. doi: 10.1186/1742-4690-8-76.
3
Control of vaccinia virus skin lesions by long-term-maintained IFN-gamma+TNF-alpha+ effector/memory CD4+ lymphocytes in humans.人类中长效维持的 IFN-γ+TNF-α+效应/记忆性 CD4+淋巴细胞对牛痘病毒皮肤损伤的控制。
J Clin Invest. 2010 May;120(5):1636-44. doi: 10.1172/JCI38506. Epub 2010 Apr 1.
4
The cytolytic enzymes granyzme A, granzyme B, and perforin: expression patterns, cell distribution, and their relationship to cell maturity and bright CD57 expression.细胞溶解酶颗粒酶A、颗粒酶B和穿孔素：表达模式、细胞分布及其与细胞成熟度和明亮CD57表达的关系。
J Leukoc Biol. 2009 Jan;85(1):88-97. doi: 10.1189/jlb.0208107. Epub 2008 Oct 10.
5
Human HLA-DR transgenes protect mice from fatal virus-induced encephalomyelitis and chronic demyelination.人类HLA - DR转基因可保护小鼠免受致命病毒诱导的脑脊髓炎和慢性脱髓鞘疾病的侵害。
J Virol. 2008 Apr;82(7):3369-80. doi: 10.1128/JVI.02243-07. Epub 2008 Jan 30.
6
Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturation.巨细胞病毒特异性CD4 + T淋巴细胞随着细胞成熟获得直接抗病毒效应功能。
J Exp Med. 2006 Dec 25;203(13):2865-77. doi: 10.1084/jem.20052246. Epub 2006 Dec 11.
7
The physiological role of cytotoxic CD4(+) T-cells: the holy grail?细胞毒性CD4(+) T细胞的生理作用：圣杯？
Clin Exp Immunol. 2004 Oct;138(1):10-3. doi: 10.1111/j.1365-2249.2004.02605.x.
8
Beyond help: direct effector functions of human immunodeficiency virus type 1-specific CD4(+) T cells.无可挽救：1型人类免疫缺陷病毒特异性CD4(+) T细胞的直接效应功能
J Virol. 2004 Aug;78(16):8844-51. doi: 10.1128/JVI.78.16.8844-8851.2004.
9
Characterization of human immunodeficiency virus type 1 (HIV-1) Gag- and Gag peptide-specific CD4(+) T-cell clones from an HIV-1-seronegative donor following in vitro immunization.体外免疫后，对一名HIV-1血清阴性供体的1型人类免疫缺陷病毒（HIV-1）Gag及Gag肽特异性CD4(+) T细胞克隆的鉴定
J Virol. 2002 Jul;76(14):6987-99. doi: 10.1128/jvi.76.14.6987-6999.2002.
10
Multiple effector functions mediated by human immunodeficiency virus-specific CD4(+) T-cell clones.人免疫缺陷病毒特异性CD4(+) T细胞克隆介导的多种效应功能。
J Virol. 2001 Oct;75(20):9771-9. doi: 10.1128/JVI.75.20.9771-9779.2001.

本文引用的文献

1
Human cytotoxic T cell clones directed against herpes simplex virus-infected cells. I. Lysis restricted by HLA class II MB and DR antigens.针对单纯疱疹病毒感染细胞的人细胞毒性T细胞克隆。I. 由HLA II类MB和DR抗原限制的裂解作用
J Immunol. 1984 Jul;133(1):422-7.
2
Cytotoxic t cells in cytomegalovirus infection: HLA-restricted T-lymphocyte and non-T-lymphocyte cytotoxic responses correlate with recovery from cytomegalovirus infection in bone-marrow-transplant recipients.巨细胞病毒感染中的细胞毒性T细胞：骨髓移植受者中HLA限制性T淋巴细胞和非T淋巴细胞的细胞毒性反应与巨细胞病毒感染的恢复相关。
N Engl J Med. 1982 Jul 1;307(1):7-13. doi: 10.1056/NEJM198207013070102.
3
Influenza virus-specific human cytotoxic T cell clones: heterogeneity in antigenic specificity and restriction by class II MHC products.流感病毒特异性人细胞毒性T细胞克隆：抗原特异性的异质性及受II类主要组织相容性复合体产物的限制
Cell Immunol. 1984 Oct 1;88(1):193-206. doi: 10.1016/0008-8749(84)90064-9.
4
Measles virus-specific T4+ human cytotoxic T cell clones are restricted by class II HLA antigens.麻疹病毒特异性T4 +人类细胞毒性T细胞克隆受II类HLA抗原限制。
J Immunol. 1984 Aug;133(2):754-7.
5
The class II molecules of the human and murine major histocompatibility complex.人类和小鼠主要组织相容性复合体的II类分子
Cell. 1984 Jan;36(1):1-13. doi: 10.1016/0092-8674(84)90068-0.
6
A hypothetical model of the foreign antigen binding site of class II histocompatibility molecules.II类组织相容性分子的外来抗原结合位点的假设模型。
Nature. 1988 Apr 28;332(6167):845-50. doi: 10.1038/332845a0.
7
Cytoimmunotherapy for persistent virus infection reveals a unique clearance pattern from the central nervous system.针对持续性病毒感染的细胞免疫疗法揭示了一种独特的从中枢神经系统清除的模式。
Nature. 1986;321(6067):239-43. doi: 10.1038/321239a0.
8
The antigen-specific, major histocompatibility complex-restricted receptor on T cells.T细胞上的抗原特异性、主要组织相容性复合体限制受体。
Adv Immunol. 1986;38:1-30. doi: 10.1016/s0065-2776(08)60005-x.
9
Phenotypic heterogeneity of cerebrospinal fluid-derived HIV-specific and HLA-restricted cytotoxic T-cell clones.脑脊液来源的HIV特异性和HLA限制性细胞毒性T细胞克隆的表型异质性。
Nature. 1988 Sep 8;335(6186):178-81. doi: 10.1038/335178a0.
10
Identical V beta T-cell receptor genes used in alloreactive cytotoxic and antigen plus I-A specific helper T cells.同种异体反应性细胞毒性T细胞和抗原加I-A特异性辅助性T细胞中使用相同的VβT细胞受体基因。
Nature. 1985;315(6018):425-7. doi: 10.1038/315425a0.