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HIV感染患者的隐球菌性脑膜炎

Cryptococcal Meningitis in HIV-Infected Patients.

作者信息

Powderly WG

机构信息

Division of Infectious Diseases, Washington University School of Medicine, 660 S. Euclid, St. Louis, MO 63110, USA.

出版信息

Curr Infect Dis Rep. 2000 Aug;2(4):352-357. doi: 10.1007/s11908-000-0015-y.

DOI:10.1007/s11908-000-0015-y
PMID:11095877
Abstract

Cryptococcosis is a fungal infection that is potentially deadly for and common among AIDS patients, in the United States and worldwide. Subacute meningitis and meningoencephalitis are typical, clinically. This article will review relevant aspects of cryptococcal meningitis in AIDS, focusing on the most recent information pertaining to pathogenesis, epidemiology, clinical syndromes, and treatment of this devastating disease.

摘要

隐球菌病是一种真菌感染，在美国及全球范围内，对艾滋病患者来说，它具有潜在致命性且较为常见。临床上，亚急性脑膜炎和脑膜脑炎很典型。本文将回顾艾滋病患者隐球菌性脑膜炎的相关方面，重点关注有关这种毁灭性疾病的发病机制、流行病学、临床综合征及治疗的最新信息。

相似文献

1
Cryptococcal Meningitis in HIV-Infected Patients.HIV感染患者的隐球菌性脑膜炎
Curr Infect Dis Rep. 2000 Aug;2(4):352-357. doi: 10.1007/s11908-000-0015-y.
2
Cryptococcal Meningoencephalitis in Phenotypically Normal Patients.表型正常患者的新型隐球菌性脑膜脑炎
Pathogens. 2023 Oct 31;12(11):1303. doi: 10.3390/pathogens12111303.
3
Cryptococcal pneumonia in AIDS: is cryptococcal meningitis preceded by clinically recognizable pneumonia?艾滋病患者的隐球菌肺炎：隐球菌性脑膜炎之前是否存在临床可识别的肺炎？
J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jun 1;9(2):168-71.
4
CD4 T Cells Orchestrate Lethal Immune Pathology despite Fungal Clearance during Meningoencephalitis.CD4 T 细胞在脑膜脑炎中尽管清除了真菌，但仍能协调致命的免疫病理。
mBio. 2017 Nov 21;8(6):e01415-17. doi: 10.1128/mBio.01415-17.
5
Fluconazole monotherapy for cryptococcosis in non-AIDS patients.氟康唑单药治疗非艾滋病患者的隐球菌病。
Eur J Clin Microbiol Infect Dis. 1996 Oct;15(10):787-92. doi: 10.1007/BF01701520.
6
Cryptococcal antigen negative meningoencephalitis in HIV/AIDS.HIV/AIDS患者的隐球菌抗原阴性脑膜脑炎
Diagn Microbiol Infect Dis. 2017 Oct;89(2):143-145. doi: 10.1016/j.diagmicrobio.2017.06.016. Epub 2017 Jul 3.
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Cryptococcal meningitis in HIV infected: experience from a North Indian tertiary center.HIV 感染患者的隐球菌性脑膜炎：来自印度北部一家三级医疗中心的经验。
Neurol India. 2008 Oct-Dec;56(4):444-9.
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Preventing deaths from cryptococcal meningitis: from bench to bedside.预防隐球菌性脑膜炎死亡：从基础到临床。
Expert Rev Anti Infect Ther. 2011 Sep;9(9):715-7. doi: 10.1586/eri.11.86.
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Invasive fungal infection by Cryptococcus neoformans var. grubii with bone marrow and meningeal involvement in a HIV-infected patient: a case report.新型隐球菌变种格卢氏菌骨髓和脑膜侵犯合并 HIV 感染患者的侵袭性真菌感染：一例报告。
BMC Infect Dis. 2019 Mar 4;19(1):220. doi: 10.1186/s12879-019-3831-8.
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Cryptococcal meningitis associated with acquired immunodeficiency syndrome (AIDS) in African patients: treatment with fluconazole.非洲患者中与获得性免疫缺陷综合征（艾滋病）相关的隐球菌性脑膜炎：氟康唑治疗
J Med Vet Mycol. 1992;30(1):71-8. doi: 10.1080/02681219280000091.

引用本文的文献

1
Inositol Metabolism Regulates Capsule Structure and Virulence in the Human Pathogen Cryptococcus neoformans.肌醇代谢调控人类病原体新型隐球菌荚膜结构和毒力。
mBio. 2021 Dec 21;12(6):e0279021. doi: 10.1128/mBio.02790-21. Epub 2021 Nov 2.
2
Brain inositol is a novel stimulator for promoting Cryptococcus penetration of the blood-brain barrier.脑肌醇是一种新型刺激剂，可促进隐球菌穿透血脑屏障。
PLoS Pathog. 2013;9(4):e1003247. doi: 10.1371/journal.ppat.1003247. Epub 2013 Apr 4.
3
Molecular mechanisms of cryptococcal meningitis.新型隐球菌性脑膜炎的分子机制。

本文引用的文献

1
Diagnosis and management of increased intracranial pressure in patients with AIDS and cryptococcal meningitis. The NIAID Mycoses Study Group and AIDS Cooperative Treatment Groups.艾滋病合并隐球菌性脑膜炎患者颅内压升高的诊断与管理。美国国立过敏与传染病研究所真菌病研究组及艾滋病协作治疗组。
Clin Infect Dis. 2000 Jan;30(1):47-54. doi: 10.1086/313603.
2
Cytokine profiles of AIDS patients are similar to those of mice with disseminated Cryptococcus neoformans infection.艾滋病患者的细胞因子谱与播散性新型隐球菌感染小鼠的细胞因子谱相似。
Infect Immun. 1999 Dec;67(12):6314-20. doi: 10.1128/IAI.67.12.6314-6320.1999.
3
Quantitative and qualitative differences in the serum antibody profiles of human immunodeficiency virus-infected persons with and without Cryptococcus neoformans meningitis.
Virulence. 2012 Mar-Apr;3(2):173-81. doi: 10.4161/viru.18685. Epub 2012 Mar 1.
4
Voriconazole, combined with amphotericin B, in the treatment for pulmonary cryptococcosis caused by C. neoformans (serotype A) in mice with severe combined immunodeficiency (SCID).氟康唑联合两性霉素 B 治疗严重联合免疫缺陷（SCID）小鼠新型隐球菌（血清型 A）引起的肺部隐球菌病。
Mycopathologia. 2012 Jun;173(5-6):445-9. doi: 10.1007/s11046-011-9499-2. Epub 2011 Nov 10.
5
Diagnostic value of latex agglutination in cryptococcal meningitis.乳胶凝集试验在隐球菌性脑膜炎中的诊断价值
J Lab Physicians. 2009 Jul;1(2):67-8. doi: 10.4103/0974-2727.59702.
6
Combination efficacy of voriconazole and amphotericin B in the experimental disease in immunodeficient mice caused by fluconazole-resistant Cryptococcus neoformans.氟康唑耐药新型隐球菌在免疫缺陷小鼠体内引起的实验性疾病中伏立康唑和两性霉素 B 的联合疗效。
Mycopathologia. 2011 Apr;171(4):261-6. doi: 10.1007/s11046-010-9375-5. Epub 2010 Oct 24.
7
Cryptococcus neoformans senses CO2 through the carbonic anhydrase Can2 and the adenylyl cyclase Cac1.新型隐球菌通过碳酸酐酶Can2和腺苷酸环化酶Cac1感知二氧化碳。
Eukaryot Cell. 2006 Jan;5(1):103-11. doi: 10.1128/EC.5.1.103-111.2006.
8
Fungal cell wall septation and cytokinesis are inhibited by bleomycins.博来霉素可抑制真菌细胞壁的分隔和胞质分裂。
Antimicrob Agents Chemother. 2003 Oct;47(10):3281-9. doi: 10.1128/AAC.47.10.3281-3289.2003.
患有和未患有新型隐球菌性脑膜炎的人类免疫缺陷病毒感染者血清抗体谱的定量和定性差异。
J Infect Dis. 1999 Nov;180(5):1526-35. doi: 10.1086/315102.
4
1999 USPHS/IDSA guidelines for the prevention of opportunistic infections in persons infected with human immunodeficiency virus. U.S. Public Health Service (USPHS) and Infectious Diseases Society of America (IDSA).1999年美国公共卫生署/美国传染病学会关于预防人类免疫缺陷病毒感染者机会性感染的指南。美国公共卫生署（USPHS）和美国传染病学会（IDSA）。
MMWR Recomm Rep. 1999 Aug 20;48(RR-10):1-59, 61-6.
5
Mediastinal lymphadenitis due to cryptococcal infection in HIV-positive patients on highly active antiretroviral therapy.
Chest. 1999 Sep;116(3):848-9. doi: 10.1378/chest.116.3.848-a.
6
Epidemiological evidence for dormant Cryptococcus neoformans infection.新型隐球菌潜伏感染的流行病学证据。
J Clin Microbiol. 1999 Oct;37(10):3204-9. doi: 10.1128/JCM.37.10.3204-3209.1999.
7
Changes in AIDS-defining illnesses in a London Clinic, 1987-1998.1987 - 1998年伦敦一家诊所中艾滋病界定疾病的变化情况。
J Acquir Immune Defic Syndr. 1999 Aug 15;21(5):401-7.
8
Itraconazole prophylaxis for fungal infections in patients with advanced human immunodeficiency virus infection: randomized, placebo-controlled, double-blind study. National Institute of Allergy and Infectious Diseases Mycoses Study Group.伊曲康唑预防晚期人类免疫缺陷病毒感染患者真菌感染：随机、安慰剂对照、双盲研究。美国国立过敏与传染病研究所真菌病研究组
Clin Infect Dis. 1999 May;28(5):1049-56. doi: 10.1086/514744.
9
Antibodies reactive with the cryptococcal capsular polysaccharide glucuronoxylomannan are present in sera from children with and without human immunodeficiency virus infection.与隐球菌荚膜多糖葡糖醛酸木糖甘露聚糖反应的抗体存在于感染和未感染人类免疫缺陷病毒的儿童血清中。
J Infect Dis. 1999 Sep;180(3):915-9. doi: 10.1086/314953.
10
Use of cerebrospinal fluid shunt for the management of elevated intracranial pressure in a patient with active AIDS-related cryptococcal meningitis.使用脑脊液分流术治疗一名患有活动性艾滋病相关隐球菌性脑膜炎且颅内压升高的患者。
Diagn Microbiol Infect Dis. 1999 Jun;34(2):111-4. doi: 10.1016/s0732-8893(99)00025-5.