Kenyon R H, McKee K T, Zack P M, Rippy M K, Vogel A P, York C, Meegan J, Crabbs C, Peters C J
Disease Assessment Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Md.
Intervirology. 1992;33(1):23-31. doi: 10.1159/000150227.
The purpose of our work was to determine if aerosols of Junin virus can infect rhesus macaques and if the disease is the same as that produced by virus inoculated parenterally. The 6 macaques exposed to the virus by aerosol became acutely ill during the 3rd week after exposure, and all died. Three died by day 21, while the remainder died after 1 month. Junin virus was found primarily in visceral organs of those animals dying before 21 days after infection and in the central nervous system tissues from animals dying later. Histological changes were similar to those reported in rhesus monkeys after parenteral Junin viral infection. Gastrointestinal necrosis, however, was less severe in aerosol-infected animals and the associated septicemia was not seen. High levels of alpha interferon were detected by the 3rd day in all infected macaques. Experimental Argentine hemorrhagic fever induced by aerosol infection in rhesus macaques was similar to that seen after parenteral challenge and mimicked closely the clinical syndrome observed in humans.
我们这项工作的目的是确定胡宁病毒气溶胶是否能感染恒河猴，以及该疾病是否与经肠胃外接种病毒所引发的疾病相同。6只经气溶胶接触病毒的恒河猴在接触后第3周急性发病，全部死亡。3只在第21天死亡，其余的在1个月后死亡。胡宁病毒主要在感染后21天内死亡动物的内脏器官以及稍后死亡动物的中枢神经系统组织中被发现。组织学变化与恒河猴经肠胃外感染胡宁病毒后所报告的变化相似。然而，气溶胶感染动物的胃肠道坏死没那么严重，且未出现相关的败血症。在所有受感染的恒河猴中，到第3天检测到高水平的α干扰素。恒河猴经气溶胶感染诱发的实验性阿根廷出血热与经肠胃外攻击后所见相似，且与在人类中观察到的临床综合征极为相似。
