大鼠链脲佐菌素糖尿病中的远端轴索性神经病
Distal axonopathy in streptozotocin diabetes in rats.
作者信息
Chokroverty S, Seiden D, Navidad P, Cody R
机构信息
Neurology Service, VA Medical Center, Lyons, New Jersey 07939.
出版信息
Experientia. 1988 May 15;44(5):444-6. doi: 10.1007/BF01940542.
PMID:3371449
Abstract
We noted the earliest morphological changes in the motor endplates 8 weeks after the induction of streptozotocin diabetes in rats. Morphometric measurements showed reduced axonal areas of the lateral plantar and the sciatic nerves in the diabetic rats 28 but not 2 and 8 weeks after the experiment. These findings suggested distal axonopathy.
摘要
我们注意到，在给大鼠注射链脲佐菌素诱导糖尿病8周后，运动终板出现了最早的形态学变化。形态测量显示，实验28周后糖尿病大鼠的足底外侧神经和坐骨神经轴突面积减小，但在2周和8周时未出现这种情况。这些发现提示存在远端轴索性神经病。
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