Knight R T, Scabini D, Woods D L, Clayworth C C
Department of Neurology, University of California, Davis.
Brain Res. 1989 Nov 13;502(1):109-16. doi: 10.1016/0006-8993(89)90466-6.
The P3 component of the event-related potential (ERP) is generated in humans and other mammalian species when attention is drawn to infrequent stimuli. We assessed the role of subregions of human posterior association cortex in auditory P3 generation in groups of patients with focal cortical lesions. Auditory P3s were recorded to target (P3b) and unexpected novel stimuli (P3a) in monaural and dichotic signal detection experiments. Two groups of patients were studied with lesions of: (1) temporal-parietal junction including posterior superior temporal plane and adjacent caudal inferior parietal cortex; and (2) the lateral parietal lobe including the rostral inferior parietal lobe and portions of superior parietal lobe. Extensive lateral parietal cortex lesions had no effect on the P3. In contrast, discrete unilateral lesions centered in the posterior superior temporal plane eliminated both the auditory P3b and P3a at electrodes over the posterior scalp. The results indicate that auditory association cortex in the human temporal-parietal junction is critical for auditory P3 generation.
当人类和其他哺乳动物的注意力被吸引到罕见刺激时，会产生事件相关电位（ERP）的P3成分。我们评估了局灶性皮质病变患者组中人类后联合皮质亚区域在听觉P3产生中的作用。在单耳和双耳信号检测实验中，记录了针对目标（P3b）和意外新刺激（P3a）的听觉P3。对两组患者进行了研究，其病变分别为：（1）颞顶叶交界处，包括颞上回后部平面和相邻的尾侧下顶叶皮质；（2）外侧顶叶，包括喙侧下顶叶和部分上顶叶。广泛的外侧顶叶皮质病变对P3没有影响。相比之下，以颞上回后部平面为中心的离散单侧病变消除了后头皮电极处的听觉P3b和P3a。结果表明，人类颞顶叶交界处的听觉联合皮质对听觉P3的产生至关重要。
