Verleger R, Heide W, Butt C, Kömpf D
Department of Neurology, Medical University, Lübeck, FRG.
Brain Res Cogn Brain Res. 1994 Sep;2(2):103-16. doi: 10.1016/0926-6410(94)90007-8.
By recording event-related EEG potentials from patients with frontal, parietal, or temporo-parietal lesions, we wanted to determine the cortical area that is relevant to the P3b component, replicating the approach used by Knight and associates who found reduced P3bs in patients with temporo-parietal lesions. They used auditory and somatosensory stimuli. We wanted to replicate their findings in auditory and visual oddball tasks and analysed potentials evoked by targets and by standard stimuli. Temporo-parietal patients' P3bs were reduced with auditory targets and lacked a distinct Pz maximum with visual targets. Further, auditory N1 was reduced both with targets and standards, P3 to visual standards and P2 to auditory standards were reduced. Parietal patients' P3bs differed only slightly from the control group, being somewhat reduced over the lesioned hemisphere with visual stimuli. Their P3 to visual standards was, however, reduced to the same extent as was the temporo-parietal patients'. Frontal patients did not differ from the control group both in their P3b and in their P3 to standards but had a number of conspicuous features in modality-specific components. In sum, our results on P3b (as well as on N1) replicate Knight's findings, confirming his conclusion that integrity of the temporo-parietal junction is critical for P3b. Implications for hypotheses on P3 are discussed.
通过记录额叶、顶叶或颞顶叶病变患者与事件相关的脑电图电位，我们希望确定与P3b成分相关的皮层区域，采用奈特及其同事所使用的方法，他们发现颞顶叶病变患者的P3b降低。他们使用了听觉和体感刺激。我们希望在听觉和视觉oddball任务中重复他们的发现，并分析由目标刺激和标准刺激诱发的电位。颞顶叶病变患者对听觉目标的P3b降低，对视觉目标缺乏明显的Pz最大值。此外，对目标刺激和标准刺激而言，听觉N1均降低，对视觉标准刺激的P3和对听觉标准刺激的P2降低。顶叶病变患者的P3b与对照组仅有轻微差异，在视觉刺激下，病变半球上的P3b有所降低。然而，他们对视觉标准刺激的P3降低程度与颞顶叶病变患者相同。额叶病变患者的P3b以及对标准刺激的P3与对照组无差异，但在特定模态成分中有一些显著特征。总之，我们关于P3b（以及N1）的结果重复了奈特的发现，证实了他的结论，即颞顶叶交界处的完整性对P3b至关重要。并讨论了对P3假说的影响。
