混合性结缔组织病患者CD4 +淋巴细胞亚群失衡
Imbalance of CD4+ lymphocyte subsets in patients with mixed connective tissue disease.
作者信息
Becker H, Langrock A, Federlin K
机构信息
III. Medizinische Klinik und Poliklinik, Universität Giessen, Germany.
出版信息
Clin Exp Immunol. 1992 Apr;88(1):91-5. doi: 10.1111/j.1365-2249.1992.tb03044.x.
Abstract
CD4+ (helper/inducer) T lymphocyte subsets were studied in the peripheral blood from patients with mixed connective tissue disease (MCTD) by double-labelling immunofluorescence. The proportion of CD4+CD45RA+ cells was higher (P less than 0.01) when compared with controls, whereas CD4+CD29+ cells were markedly diminished (P less than 0.001). CD4+CD29+ cells were lower than in patients with progressive systemic sclerosis who were studied in parallel. Upon stimulation with phytohaemagglutinin, CD4+ cells from MCTD patients showed a strong reactivity to acquire the CD29+ phenotype. Expression of high levels of CD29 and other adhesion molecules might lead to facilitated localization of CD4+ cells to inflamed tissue. It is suggested that an increased responsiveness of CD4+ cells to activation signals in vivo and accumulation of CD4+CD29+ cells at tissue sites could result in depletion of this cell subset in the peripheral blood of patients with MCTD.
摘要
通过双标记免疫荧光法研究了混合性结缔组织病（MCTD）患者外周血中的CD4 +（辅助/诱导）T淋巴细胞亚群。与对照组相比，CD4 + CD45RA +细胞的比例更高（P <0.01），而CD4 + CD29 +细胞明显减少（P <0.001）。CD4 + CD29 +细胞低于平行研究的进行性系统性硬化症患者。在用植物血凝素刺激后，MCTD患者的CD4 +细胞对获得CD29 +表型表现出强烈反应。高水平的CD29和其他粘附分子的表达可能导致CD4 +细胞更容易定位于炎症组织。提示CD4 +细胞在体内对激活信号的反应性增加以及CD4 + CD29 +细胞在组织部位的积累可能导致MCTD患者外周血中该细胞亚群的耗竭。
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