X射线照射会减弱兔耳动脉的舒张反应。
X-irradiation attenuates relaxant responses in the rabbit ear artery.
作者信息
Maynard K I, Stewart-Lee A L, Milner P, Burnstock G
机构信息
Department of Anatomy and Developmental Biology, University College London.
出版信息
Br J Pharmacol. 1992 Jan;105(1):126-8. doi: 10.1111/j.1476-5381.1992.tb14222.x.
Abstract
- The relaxant actions of acetylcholine, substance P and calcitonin gene-related peptide, and the levels of neuropeptide Y and calcitonin gene-related peptide were assessed in the rabbit central ear artery 1, 4 and 6 weeks after a single dose of 45 Gy X-irradiation, a dose similar to that used clinically in intraoperative radiotherapy. 2. Relaxant responses induced by acetylcholine and substance P (both endothelium-dependent) and calcitonin gene-related peptide (endothelium-independent) were reduced, and endogenous neuropeptide Y and calcitonin gene-related peptide levels were unaffected after X-irradiation. 3. The mechanism(s) by which a single dose of 45 Gy X-irradiation may selectively damage relaxant, but not direct, contractile responses of the smooth muscle (as we have shown previously) of the rabbit central ear artery are discussed.
摘要
- 在单次给予45 Gy X射线照射（该剂量与术中放疗临床使用剂量相似）后1周、4周和6周，对兔中耳动脉中乙酰胆碱、P物质和降钙素基因相关肽的舒张作用以及神经肽Y和降钙素基因相关肽的水平进行了评估。2. X射线照射后，乙酰胆碱和P物质（两者均为内皮依赖性）以及降钙素基因相关肽（内皮非依赖性）诱导的舒张反应降低，而内源性神经肽Y和降钙素基因相关肽水平未受影响。3. 讨论了单次45 Gy X射线照射可能选择性损伤兔中耳动脉平滑肌舒张反应（如我们之前所示）而非直接收缩反应的机制。
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本文引用的文献
1
Clinical experiences with intraoperative radiotherapy of locally advanced cancers.局部晚期癌症术中放疗的临床经验。
Cancer. 1980 Jan 1;45(1):40-8. doi: 10.1002/1097-0142(19800101)45:1<40::aid-cncr2820450108>3.0.co;2-2.
2
The outlook for intraoperative radiotherapy.术中放疗的前景。
Int J Radiat Oncol Biol Phys. 1981 Jul;7(7):979-80. doi: 10.1016/0360-3016(81)90020-1.
3
Intraoperative radiotherapy: the Japanese experience.术中放疗：日本的经验
Int J Radiat Oncol Biol Phys. 1981 Jul;7(7):863-8. doi: 10.1016/0360-3016(81)90001-8.
4
Acetylcholine induced endothelial-dependent vasodilation increases as artery diameter decreases in the rabbit ear.在兔耳中，随着动脉直径减小，乙酰胆碱诱导的内皮依赖性血管舒张增加。
Experientia. 1985 Aug 15;41(8):1057-8. doi: 10.1007/BF01952142.
5
Preoperative, intraoperative, and postoperative radiation in the treatment of primary soft tissue sarcoma.
Cancer. 1985 Jun 1;55(11):2659-67. doi: 10.1002/1097-0142(19850601)55:11<2659::aid-cncr2820551122>3.0.co;2-q.
6
Intraoperative irradiation of the canine abdominal aorta and vena cava.
Int J Radiat Oncol Biol Phys. 1987 May;13(5):715-22. doi: 10.1016/0360-3016(87)90290-2.
7
Vascular lesions following radiation.放疗后的血管病变
Pathol Annu. 1988;23 Pt 1:297-330.
8
Peptides in the mammalian cardiovascular system.哺乳动物心血管系统中的肽类物质。
Experientia. 1987 Jul 15;43(7):821-32. doi: 10.1007/BF01945360.
9
Pre- and postjunctional effects of neuropeptide Y on the rabbit isolated ear artery.神经肽Y对兔离体耳动脉的节前和节后效应
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10
Aortic wall injury following intraoperative irradiation.术中放疗后主动脉壁损伤
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