Christensen M M, Ernst E, Ellermann-Eriksen S
Institute of Medical Microbiology, University of Aarhus, Denmark.
Arch Toxicol. 1992;66(5):347-53. doi: 10.1007/BF01973630.
The in vitro effect of hexavalent chromium (CrVI) on mouse peritoneal macrophages was investigated. Our results demonstrate the existence of a threshold concentration of 2.5 microM of CrVI above which chromium affects the viability of macrophages in a concentration dependent manner. Morphological changes were seen with increasing concentrations of chromium. Evidence is presented that protein production (virus-induced interferon) in murine peritoneal macrophages was impaired by hexavalent chromium at low concentrations, while random migration and phagocytic activity were only affected at high concentrations of CrVI.
研究了六价铬（CrVI）对小鼠腹腔巨噬细胞的体外作用。我们的结果表明，存在一个2.5微摩尔的六价铬阈值浓度，高于此浓度，铬以浓度依赖的方式影响巨噬细胞的活力。随着铬浓度的增加，可见形态学变化。有证据表明，低浓度的六价铬会损害小鼠腹腔巨噬细胞中的蛋白质产生（病毒诱导的干扰素），而随机迁移和吞噬活性仅在高浓度的六价铬时受到影响。
