两组小鼠基因的相互作用决定了泰勒氏病毒在中枢神经系统中的持续存在。
The interaction of two groups of murine genes determines the persistence of Theiler's virus in the central nervous system.
作者信息
Bureau J F, Montagutelli X, Lefebvre S, Guénet J L, Pla M, Brahic M
机构信息
Unité des Virus Lents, UA 1157, Centre National de la Recherche Scientifique, Institut Pasteur, Paris, France.
出版信息
J Virol. 1992 Aug;66(8):4698-704. doi: 10.1128/JVI.66.8.4698-4704.1992.
Abstract
Theiler's murine encephalomyelitis virus is responsible for a chronic inflammatory demyelinating disease of the central nervous system of the mouse. The disease is associated with persistent viral infection of the spinal cord. Some strains of mice are susceptible to viral infection, and other strains are resistant. The effect of the genetic background of the host on viral persistence has not been thoroughly investigated. We studied the amount of viral RNA in the spinal cords of 17 inbred strains of mice and their F1 crosses with the SJL/J strain and observed a large degree of variability among strains. The pattern of viral persistence among mouse strains could be explained by the interaction of two loci. One locus is localized in the H-2D region of the major histocompatibility complex, whereas the other locus is outside this complex and is not linked to the Tcrb locus on chromosome 6.
摘要
泰勒氏鼠脑脊髓炎病毒可引发小鼠中枢神经系统的慢性炎性脱髓鞘疾病。该疾病与脊髓的持续性病毒感染有关。一些品系的小鼠易受病毒感染，而其他品系则具有抗性。宿主遗传背景对病毒持续性的影响尚未得到充分研究。我们研究了17个近交系小鼠及其与SJL/J品系的F1杂交后代脊髓中的病毒RNA含量，观察到品系间存在很大差异。小鼠品系间病毒持续性的模式可由两个基因座的相互作用来解释。一个基因座位于主要组织相容性复合体的H-2D区域，而另一个基因座在该复合体外，且与6号染色体上的Tcrb基因座不连锁。
相似文献
1
The interaction of two groups of murine genes determines the persistence of Theiler's virus in the central nervous system.两组小鼠基因的相互作用决定了泰勒氏病毒在中枢神经系统中的持续存在。
J Virol. 1992 Aug;66(8):4698-704. doi: 10.1128/JVI.66.8.4698-4704.1992.
2
Persistent infection of a glioma cell line generates a Theiler's virus variant which fails to induce demyelinating disease in SJL/J mice.一种胶质瘤细胞系的持续感染产生了一种泰勒氏病毒变体，该变体无法在SJL/J小鼠中诱发脱髓鞘疾病。
J Gen Virol. 1990 Sep;71 ( Pt 9):2123-32. doi: 10.1099/0022-1317-71-9-2123.
3
Theiler's virus infection in nude mice: viral RNA in vascular endothelial cells.裸鼠中的泰勒病毒感染：血管内皮细胞中的病毒RNA
J Virol. 1988 Oct;62(10):3589-96. doi: 10.1128/JVI.62.10.3589-3596.1988.
4
5
Mapping loci influencing the persistence of Theiler's virus in the murine central nervous system.定位影响泰勒氏病毒在小鼠中枢神经系统中持续存在的基因座。
Nat Genet. 1993 Sep;5(1):87-91. doi: 10.1038/ng0993-87.
6
Coexpression of class I major histocompatibility antigen and viral RNA in central nervous system of mice infected with Theiler's virus: a model for multiple sclerosis.I类主要组织相容性抗原与病毒RNA在感染泰勒氏病毒的小鼠中枢神经系统中的共表达：一种多发性硬化症模型
Mayo Clin Proc. 1992 Sep;67(9):829-38. doi: 10.1016/s0025-6196(12)60820-9.
7
Genetic analysis of susceptibility to Theiler's virus-induced demyelinating disease in mice.小鼠对泰勒氏病毒诱导的脱髓鞘疾病易感性的遗传分析。
J Immunol. 1984 Apr;132(4):1821-5.
8
Major histocompatibility complex-conferred resistance to Theiler's virus-induced demyelinating disease is inherited as a dominant trait in B10 congenic mice.主要组织相容性复合体赋予的对泰勒氏病毒诱导的脱髓鞘疾病的抗性在B10同源基因小鼠中作为显性性状遗传。
J Virol. 1990 Nov;64(11):5570-6. doi: 10.1128/JVI.64.11.5570-5576.1990.
9
The 5' noncoding sequences from a less virulent Theiler's virus dramatically attenuate GDVII neurovirulence.一种低毒力泰勒病毒的5'非编码序列可显著减弱GDVII的神经毒力。
J Virol. 1991 Aug;65(8):4370-7. doi: 10.1128/JVI.65.8.4370-4377.1991.
10
Demyelinating lesions due to Theiler's virus are associated with ongoing central nervous system infection.由泰勒氏病毒引起的脱髓鞘病变与中枢神经系统持续感染有关。
J Virol. 1986 Mar;57(3):992-7. doi: 10.1128/JVI.57.3.992-997.1986.
引用本文的文献
1
Excessive Innate Immunity Steers Pathogenic Adaptive Immunity in the Development of Theiler's Virus-Induced Demyelinating Disease.过度的先天免疫在泰勒病毒诱导的脱髓鞘疾病发展过程中引导致病性适应性免疫。
Int J Mol Sci. 2021 May 17;22(10):5254. doi: 10.3390/ijms22105254.
2
Suppression of Non-Random Fertilization by MHC Class I Antigens.MHC Ⅰ类抗原对非随机受精的抑制作用。
Int J Mol Sci. 2020 Nov 19;21(22):8731. doi: 10.3390/ijms21228731.
3
Long Noncoding RNAs in Host-Pathogen Interactions.长非编码 RNA 在宿主-病原体相互作用中的作用。
Trends Immunol. 2019 Jun;40(6):492-510. doi: 10.1016/j.it.2019.04.001. Epub 2019 Apr 30.
4
Characterization of Plaque-Sized Variants of Daniel's (DA) Strain in Theiler's Virus-Induced Epilepsy.Daniel's (DA) 株斑块大小变异体的特征在 Theiler 病毒诱导的癫痫中的表现。
Sci Rep. 2019 Mar 5;9(1):3444. doi: 10.1038/s41598-019-38967-z.
5
Deficient Natural Killer Dendritic Cell Responses Underlay the Induction of Theiler's Virus-Induced Autoimmunity.自然杀伤树突状细胞反应缺陷是泰勒氏病毒诱导自身免疫的基础。
mBio. 2015 Aug 4;6(4):e01175. doi: 10.1128/mBio.01175-15.
6
The level of viral infection of antigen-presenting cells correlates with the level of development of Theiler's murine encephalomyelitis virus-induced demyelinating disease.抗原呈递细胞的病毒感染水平与泰勒氏鼠脑脊髓炎病毒诱导的脱髓鞘疾病的发展程度相关。
J Virol. 2015 Feb;89(3):1867-78. doi: 10.1128/JVI.02471-14. Epub 2014 Nov 26.
7
Long noncoding RNAs during normal and malignant hematopoiesis.正常和恶性造血过程中的长链非编码RNA
Int J Hematol. 2014;99(5):531-41. doi: 10.1007/s12185-014-1552-8. Epub 2014 Mar 9.
8
The NeST long ncRNA controls microbial susceptibility and epigenetic activation of the interferon-γ locus.NeST 长 ncRNA 控制微生物易感性和干扰素-γ基因座的表观遗传激活。
Cell. 2013 Feb 14;152(4):743-54. doi: 10.1016/j.cell.2013.01.015.
9
Identification of a novel neuropathogenic Theiler's murine encephalomyelitis virus.鉴定一种新型致神经病变的小鼠脑脊髓炎病毒。
J Virol. 2011 Jul;85(14):6893-905. doi: 10.1128/JVI.00274-11. Epub 2011 May 4.
10
Preferential induction of protective T cell responses to Theiler's virus in resistant (C57BL/6 x SJL)F1 mice.优先诱导抵抗（C57BL/6 x SJL）F1 小鼠对 Theiler 病毒的保护性 T 细胞反应。
J Virol. 2011 Mar;85(6):3033-40. doi: 10.1128/JVI.02400-10. Epub 2010 Dec 29.
本文引用的文献
1
DA strain of Theiler's murine encephalomyelitis virus induces demyelination in nude mice.泰勒氏小鼠脑脊髓炎病毒的DA毒株可在裸鼠中诱发脱髓鞘病变。
Ann Neurol. 1984 May;15(5):494-9. doi: 10.1002/ana.410150516.
2
Genetic analysis of susceptibility to Theiler's virus-induced demyelinating disease in mice.小鼠对泰勒氏病毒诱导的脱髓鞘疾病易感性的遗传分析。
J Immunol. 1984 Apr;132(4):1821-5.
3
Persistent infection of oligodendrocytes in Theiler's virus-induced encephalomyelitis.泰勒氏病毒诱导的脑脊髓炎中少突胶质细胞的持续感染。
Ann Neurol. 1983 Apr;13(4):426-33. doi: 10.1002/ana.410130409.
4
The effect of short-term and chronic immunosuppression on Theiler's virus demyelination.短期和慢性免疫抑制对泰勒氏病毒脱髓鞘的影响。
J Neuroimmunol. 1982 Jun;2(3-4):223-34. doi: 10.1016/0165-5728(82)90057-1.
5
Theiler's virus antigen detected in mouse spinal cord 2 1/2 years after infection.感染后2年半在小鼠脊髓中检测到泰勒氏病毒抗原。
Neurology. 1984 Aug;34(8):1117-9. doi: 10.1212/wnl.34.8.1117.
6
Demyelinating lesions due to Theiler's virus are associated with ongoing central nervous system infection.由泰勒氏病毒引起的脱髓鞘病变与中枢神经系统持续感染有关。
J Virol. 1986 Mar;57(3):992-7. doi: 10.1128/JVI.57.3.992-997.1986.
7
8
Theiler's virus RNA and protein synthesis in the central nervous system of demyelinating mice.脱髓鞘小鼠中枢神经系统中泰勒氏病毒的RNA和蛋白质合成
Virology. 1985 Jul 15;144(1):290-4. doi: 10.1016/0042-6822(85)90327-7.
9
Mechanism of Theiler's virus-induced demyelination in nude mice.泰勒氏病毒诱导裸鼠脱髓鞘的机制。
Lab Invest. 1986 May;54(5):515-22.
10
Partial suppression of Theiler's virus-induced demyelination in vivo by administration of monoclonal antibodies to immune-response gene products (Ia antigens).通过给予针对免疫反应基因产物（Ia抗原）的单克隆抗体，在体内部分抑制泰勒氏病毒诱导的脱髓鞘。
Neurology. 1986 Jul;36(7):964-70. doi: 10.1212/wnl.36.7.964.
Zotero 插件