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为什么肿瘤细胞具有较高的有氧糖酵解作用?

Why do tumor cells have a high aerobic glycolysis?

作者信息

Racker E

出版信息

J Cell Physiol. 1976 Dec;89(4):697-700. doi: 10.1002/jcp.1040890429.

Abstract

In Ehrlich ascites cells and several other tumors, the high aerobic glycolysis is maintained by generation of ADP and Pi by the plasma membrane Na+K+ ATPase. The high ATP activity is caused by a defective pump that operates at a low efficiency. Studies of the mechanism of action of the Na+K+ ATPase and other pump ATPases suggest several alternative mechanisms that might account for the decreased efficiency. The possibility of involvement of a proteolipid is under investigation.

摘要

在艾氏腹水癌细胞和其他几种肿瘤中,质膜Na⁺K⁺ATP酶产生ADP和无机磷酸维持了高有氧糖酵解。高ATP活性是由一个低效运转的有缺陷的泵所导致的。对Na⁺K⁺ATP酶及其他泵ATP酶作用机制的研究提示了几种可能解释效率降低的替代机制。一种蛋白脂质参与其中的可能性正在研究中。

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