视锥视觉色素存在于壁虎的视杆细胞中。
Cone visual pigments are present in gecko rod cells.
作者信息
Kojima D, Okano T, Fukada Y, Shichida Y, Yoshizawa T, Ebrey T G
机构信息
Department of Biophysics, Faculty of Science, Kyoto University, Japan.
出版信息
Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):6841-5. doi: 10.1073/pnas.89.15.6841.
The Tokay gecko (Gekko gekko), a nocturnal lizard, has two kinds of visual pigments, P467 and P521. In spite of the pure-rod morphology of the photoreceptor cells, the biochemical properties of P521 and P467 resemble those of iodopsin (the chicken red-sensitive cone visual pigment) and rhodopsin, respectively. We have found that the amino acid sequence of P521 deduced from the cDNA was very similar to that of iodopsin. In addition, P467 has the highest homology with the chicken green-sensitive cone visual pigment, although it also has a relatively high homology with rhodopsins. These results give additional strength to the transmutation theory of Walls [Walls, G. L. (1934) Am. J. Ophthalmol. 17, 892-915], who proposed that the rod-shaped photoreceptor cells of lizards have been derived from ancestral cone-like photoreceptors. Apparently amino acid sequences of visual pigments are less changeable than the morphology of the photoreceptor cells in the course of evolution.
大壁虎（蛤蚧）是一种夜行性蜥蜴，具有两种视觉色素，即P467和P521。尽管光感受器细胞具有纯视杆形态，但P521和P467的生化特性分别类似于视锥视蛋白（鸡的红色敏感视锥视觉色素）和视紫红质。我们发现，从cDNA推导的P521氨基酸序列与视锥视蛋白非常相似。此外，P467与鸡的绿色敏感视锥视觉色素具有最高的同源性，尽管它与视紫红质也有相对较高的同源性。这些结果进一步支持了沃尔斯的转化理论[沃尔斯，G.L.（1934年）《美国眼科杂志》17卷，892 - 915页]，他提出蜥蜴的杆状光感受器细胞源自祖先的锥状光感受器。显然，在进化过程中，视觉色素的氨基酸序列比光感受器细胞的形态变化更小。
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