白细胞介素-8抑制大鼠腹腔中性粒细胞中一氧化氮合酶的诱导。
Interleukin-8 inhibits the induction of nitric oxide synthase in rat peritoneal neutrophils.
作者信息
McCall T B, Palmer R M, Moncada S
机构信息
Wellcome Research Laboratories, Beckenham, Kent, U.K.
出版信息
Biochem Biophys Res Commun. 1992 Jul 31;186(2):680-5. doi: 10.1016/0006-291x(92)90800-z.
The effect of interleukin(IL)-8 and leukotriene B4 (LTB4) on the induction of nitric oxide (NO) synthase in rat peritoneal neutrophils (PMN) ex vivo was studied. IL-8, but not LTB4, caused concentration-dependent inhibition of the induction of a Ca(2+)-independent NO synthase ex vivo. The effect of IL-8 was not attributable to the synthesis of an inhibitor of this enzyme. These findings suggest complex regulatory control of the induction of NO synthase by cytokines.
研究了白细胞介素（IL）-8和白三烯B4（LTB4）对大鼠腹腔中性粒细胞（PMN）离体诱导一氧化氮（NO）合酶的影响。IL-8而非LTB4可引起离体诱导的不依赖钙的NO合酶浓度依赖性抑制。IL-8的作用并非归因于该酶抑制剂的合成。这些发现提示细胞因子对NO合酶诱导存在复杂的调控。
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