通过白细胞介素-2刺激宿主防御机制可改善电化学疗法对肿瘤的治疗效果。
Electrochemotherapy tumor treatment is improved by interleukin-2 stimulation of the host's defenses.
作者信息
Mir L M, Orlowski S, Poddevin B, Belehradek J
机构信息
Laboratoire de Biochimie-Enzymologie, Institut Gustave-Roussy, Villejuif, France.
出版信息
Eur Cytokine Netw. 1992 May-Jun;3(3):331-4.
PMID:1379837
Abstract
We have recently described a new antitumor treatment, electrochemotherapy (ECT), based on the large local potentiation of the effects of the chemotherapeutic agent bleomycin (BLM) by electric pulses (EP) delivered at the tumor site. We demonstrate here that the host's immune response participates in cure achievement. We obtain an increase of the rate of completely cured animals by injecting mice with interleukin-2 (IL-2).
摘要
我们最近描述了一种新的抗肿瘤治疗方法，即电化学疗法（ECT），它基于在肿瘤部位施加电脉冲（EP）对化疗药物博来霉素（BLM）的效果产生的大幅局部增强作用。我们在此证明宿主的免疫反应参与了治愈过程。通过给小鼠注射白细胞介素-2（IL-2），我们提高了完全治愈动物的比例。
Zotero 插件