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通过白细胞介素-2刺激宿主防御机制可改善电化学疗法对肿瘤的治疗效果。

Electrochemotherapy tumor treatment is improved by interleukin-2 stimulation of the host's defenses.

作者信息

Mir L M, Orlowski S, Poddevin B, Belehradek J

机构信息

Laboratoire de Biochimie-Enzymologie, Institut Gustave-Roussy, Villejuif, France.

出版信息

Eur Cytokine Netw. 1992 May-Jun;3(3):331-4.

PMID:1379837
Abstract

We have recently described a new antitumor treatment, electrochemotherapy (ECT), based on the large local potentiation of the effects of the chemotherapeutic agent bleomycin (BLM) by electric pulses (EP) delivered at the tumor site. We demonstrate here that the host's immune response participates in cure achievement. We obtain an increase of the rate of completely cured animals by injecting mice with interleukin-2 (IL-2).

摘要

我们最近描述了一种新的抗肿瘤治疗方法,即电化学疗法(ECT),它基于在肿瘤部位施加电脉冲(EP)对化疗药物博来霉素(BLM)的效果产生的大幅局部增强作用。我们在此证明宿主的免疫反应参与了治愈过程。通过给小鼠注射白细胞介素-2(IL-2),我们提高了完全治愈动物的比例。

相似文献

1
Electrochemotherapy tumor treatment is improved by interleukin-2 stimulation of the host's defenses.通过白细胞介素-2刺激宿主防御机制可改善电化学疗法对肿瘤的治疗效果。
Eur Cytokine Netw. 1992 May-Jun;3(3):331-4.
2
Host's immune response in electrotherapy of murine tumors by direct current.直流电对小鼠肿瘤进行电疗时宿主的免疫反应
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3
[Potentiation of the antitumoral effect of electrochemotherapy by immunotherapy with allogeneic cells producing interleukin 2].
C R Acad Sci III. 1992;314(12):539-44.
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Systemic antitumor effects of electrochemotherapy combined with histoincompatible cells secreting interleukin-2.电化学疗法联合分泌白细胞介素-2的组织不相容细胞的全身抗肿瘤作用
J Immunother Emphasis Tumor Immunol. 1995 Jan;17(1):30-8. doi: 10.1097/00002371-199501000-00004.
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Antitumor effect of electrochemotherapy on colorectal carcinoma in an orthotopic mouse model.
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Effects of electrochemotherapy on CaSki cells derived from a cervical squamous cell carcinoma.电化学疗法对源自宫颈鳞状细胞癌的CaSki细胞的影响。
Gynecol Oncol. 1997 May;65(2):297-303. doi: 10.1006/gyno.1997.4659.
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[Inhibitory effect of electrochemotherapy on S180 tumor growth and angiogenesis and the possible mechanism].
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2004 Dec;21(6):888-92.
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Effective treatment of perianal tumors in dogs with electrochemotherapy.电化学疗法有效治疗犬肛周肿瘤。
Anticancer Res. 2005 Mar-Apr;25(2A):839-45.
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Tumor blood flow modifying effect of electrochemotherapy with bleomycin.博来霉素电化学疗法对肿瘤血流的影响
Anticancer Res. 1999 Sep-Oct;19(5B):4017-22.
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Electrochemotherapy on liver tumours in rabbits.兔肝脏肿瘤的电化学疗法
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