Marner I L, Friborg S, Simonsen E
Scand J Gastroenterol. 1975;10(5):537-44.
Nine different serum proteins from 50 patients suffering from ulcerative colitis were quantitated by means of Laurell's rocket-electrophoresis. The periods of study extended for up to five years. Twenty-six patients were seen at brief intervals from days up to two months; 18 patients were seen at intervals from two to six months. As surgical intervention was urgently required in six cases, few determinations were made in these patients. The disease was classified into five phases according to its clinical activity (as assessed by temperature, blood via the rectum, and number of episodes of diarrhoea). The phases are designated: active febrile; active afebrile; unstable; remission; and restitution. The concentrations of orosomucoid and haptoglobin were found to rise in parallel with intensified clinical activity, while the concentration of pre-albumin falls, thus making these proteins particularly useful for determining changes in the clinical status of the patients. The concentration of pre-albumin during the active phase was especially useful in cases where it was to be decided whether or not surgery was indicated. Concentrations of orosomucoid and IgG were not as useful as pre-albumin in these cases. In patients who escaped operation, the concentration of pre-albumin was seen to rise from low values up to normal before clinical improvement set in.
采用劳雷尔火箭电泳法对50例溃疡性结肠炎患者的9种不同血清蛋白进行了定量分析。研究期长达5年。26例患者接受了从数天到两个月不等的短期观察；18例患者接受了从两个月到六个月不等的观察。由于6例患者急需手术干预，这些患者的检测次数很少。根据临床活动情况（通过体温、直肠出血和腹泻发作次数评估）将疾病分为五个阶段。这些阶段分别为：发热活跃期；无热活跃期；不稳定期；缓解期；和恢复期。发现血清类粘蛋白和触珠蛋白的浓度随着临床活动加剧而平行升高，而前白蛋白浓度下降，因此这些蛋白质对于确定患者临床状态的变化特别有用。在决定是否需要手术的情况下，活跃期前白蛋白的浓度特别有用。在这些情况下，血清类粘蛋白和IgG的浓度不如前白蛋白有用。在未接受手术的患者中，在临床改善出现之前，前白蛋白浓度从低值升至正常。
