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Augmented immunological activities of recombinant lipopolysaccharide possessing the mannose homopolymer as the O-specific polysaccharide.以甘露糖均聚物作为O-特异性多糖的重组脂多糖增强的免疫活性。
Infect Immun. 1996 Jan;64(1):305-9. doi: 10.1128/iai.64.1.305-309.1996.
2
Potent adjuvant action of lipopolysaccharides possessing the O-specific polysaccharide moieties consisting of mannans in antibody response against protein antigen.
Cell Immunol. 1985 Mar;91(1):52-9. doi: 10.1016/0008-8749(85)90031-0.
3
Strong adjuvanticity of bacterial lipopolysaccharides possessing the homopolysaccharides consisting of mannose as the O-specific polysaccharide chains.具有以甘露糖作为O-特异性多糖链的同多糖的细菌脂多糖具有强大的佐剂活性。
Med Microbiol Immunol. 1985;174(1):1-14.
4
Evolutionary relationship among rfb gene clusters synthesizing mannose homopolymer as O-specific polysaccharides in Escherichia coli and Klebsiella.在大肠杆菌和克雷伯氏菌中合成作为O-特异性多糖的甘露糖同聚物的rfb基因簇之间的进化关系。
Gene. 1997 Oct 1;198(1-2):111-3. doi: 10.1016/s0378-1119(97)00300-4.
5
Distribution of the rol gene encoding the regulator of lipopolysaccharide O-chain length in Escherichia coli and its influence on the expression of group I capsular K antigens.编码大肠杆菌脂多糖O链长度调节剂的rol基因的分布及其对I组荚膜K抗原表达的影响。
J Bacteriol. 1996 Apr;178(7):1895-902. doi: 10.1128/jb.178.7.1895-1902.1996.
6
Cloning and analysis of duplicated rfbM and rfbK genes involved in the formation of GDP-mannose in Escherichia coli O9:K30 and participation of rfb genes in the synthesis of the group I K30 capsular polysaccharide.大肠杆菌O9:K30中参与GDP-甘露糖形成的重复rfbM和rfbK基因的克隆与分析以及rfb基因在I型K30荚膜多糖合成中的作用
J Bacteriol. 1994 Jun;176(11):3126-39. doi: 10.1128/jb.176.11.3126-3139.1994.
7
Contribution of the mannan O side-chains to the adjuvant action of lipopolysaccharides.甘露聚糖O侧链对脂多糖佐剂作用的贡献。
Immunology. 1987 Apr;60(4):503-7.
8
Novel adjuvant action of lipopolysaccharides that possess mannose homopolysaccharides as O-specific polysaccharides on immune responses to nonimmunogenic autoantigens in mice.以甘露糖同多糖作为O-特异性多糖的脂多糖对小鼠非免疫原性自身抗原免疫反应的新型佐剂作用。
Infect Immun. 1992 Nov;60(11):4953-6. doi: 10.1128/iai.60.11.4953-4956.1992.
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Binding of mannose-binding protein to Klebsiella O3 lipopolysaccharide possessing the mannose homopolysaccharide as the O-specific polysaccharide and its relation to complement activation.甘露糖结合蛋白与以甘露糖同多糖作为O-特异性多糖的肺炎克雷伯菌O3脂多糖的结合及其与补体激活的关系。
Infect Immun. 1995 Jul;63(7):2537-40. doi: 10.1128/iai.63.7.2537-2540.1995.
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Genetic analysis of the O-specific lipopolysaccharide biosynthesis region (rfb) of Escherichia coli K-12 W3110: identification of genes that confer group 6 specificity to Shigella flexneri serotypes Y and 4a.大肠杆菌K-12 W3110 O-特异性脂多糖生物合成区域（rfb）的遗传分析：赋予弗氏志贺菌血清型Y和4a第6组特异性的基因鉴定
J Bacteriol. 1994 Jul;176(13):4133-43. doi: 10.1128/jb.176.13.4133-4143.1994.

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Complement-dependent accumulation and degradation of platelets in the lung and liver induced by injection of lipopolysaccharides.注射脂多糖诱导血小板在肺和肝脏中通过补体依赖方式聚集和降解。
Infect Immun. 1999 Oct;67(10):5186-91. doi: 10.1128/IAI.67.10.5186-5191.1999.
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Generation of Escherichia coli O9a serotype, a subtype of E. coli O9, by transfer of the wb* gene cluster of Klebsiella O3 into E. coli via recombination.通过重组将肺炎克雷伯菌O3的wb*基因簇转移至大肠杆菌中，从而产生大肠杆菌O9a血清型（大肠杆菌O9的一个亚型）。
J Bacteriol. 1998 May;180(10):2775-8. doi: 10.1128/JB.180.10.2775-2778.1998.

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A murine model of experimental autoimmune lens-induced uveitis using Klebsiella O3 lipopolysaccharide as a potent immunological adjuvant.一种以肺炎克雷伯菌O3脂多糖作为强效免疫佐剂的实验性自身免疫性晶状体诱导性葡萄膜炎的小鼠模型。
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Adjuvant action of capsular polysaccharide of Klebsiella pneumoniae on antibody response. VIII. Its effect on the size and the number of cells of regional lymph node and other lymphoid organs.肺炎克雷伯菌荚膜多糖对抗体反应的佐剂作用。VIII. 其对局部淋巴结及其他淋巴器官细胞大小和数量的影响。
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Morphological heterogeneity among Salmonella lipopolysaccharide chemotypes in silver-stained polyacrylamide gels.银染聚丙烯酰胺凝胶中沙门氏菌脂多糖化学型之间的形态异质性。
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Further improvements in the plaque technique for detecting single antibody-forming cells.用于检测单个抗体形成细胞的蚀斑技术的进一步改进。
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Structural studies on the Klebsiella O group 3 lipopolysaccharide.肺炎克雷伯菌O3群脂多糖的结构研究。
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Structural studies of the O-antigen polysaccharides of Klebsiella O5 and Escherichia coli O8.肺炎克雷伯菌O5和大肠杆菌O8 O抗原多糖的结构研究。
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10
Strong adjuvanticity of bacterial lipopolysaccharides possessing the homopolysaccharides consisting of mannose as the O-specific polysaccharide chains.具有以甘露糖作为O-特异性多糖链的同多糖的细菌脂多糖具有强大的佐剂活性。
Med Microbiol Immunol. 1985;174(1):1-14.

以甘露糖均聚物作为O-特异性多糖的重组脂多糖增强的免疫活性。

Augmented immunological activities of recombinant lipopolysaccharide possessing the mannose homopolymer as the O-specific polysaccharide.

作者信息

Paeng N, Kido N, Schmidt G, Sugiyama T, Kato Y, Koide N, Yokochi T

机构信息

Department of Natural Science Informatics, School of Informatics and Sciences, Nagoya University, Aichi, Japan.

出版信息

Infect Immun. 1996 Jan;64(1):305-9. doi: 10.1128/iai.64.1.305-309.1996.

DOI:10.1128/iai.64.1.305-309.1996
PMID:8557356
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC173760/
Abstract

Recombinant lipopolysaccharide possessing the mannose homopolymer as the O-specific polysaccharide was manufactured genetically by transforming Escherichia coli K-12 with various rfb genes capable of synthesizing the mannose homopolymer. Recombinant lipopolysaccharide exhibited levels of anticomplement activity, adjuvant activity, and regional lymph node-enlarging activity much higher than those exhibited by the original rough-type lipopolysaccharide from E. coli K-12 or lipopolysaccharide possessing the heteropolysaccharide from E. coli O111. Immunological activities of recombinant lipopolysaccharide were as strong as those of wild-type lipopolysaccharide possessing the mannose homopolymer. Characteristic activities of wild-type lipolysaccharide possessing the mannose homopolymer were exhibited by recombinant lipopolysaccharide. The abilities of lipopolysaccharide to activate B cells polyclonally and to produce cytokines did not seem to be related to the presence of the mannose homopolymer. Therefore, it was suggested that the mannose homopolymer in the O-specific polysaccharide might exclusively enhance anticomplement activity, adjuvant activity, and regional lymph node-enlarging activity among various lipid A activities.

摘要

通过用各种能够合成甘露糖同聚物的rfb基因转化大肠杆菌K - 12，从基因层面制造出了以甘露糖同聚物作为O - 特异性多糖的重组脂多糖。重组脂多糖表现出的抗补体活性、佐剂活性和局部淋巴结肿大活性水平，比大肠杆菌K - 12的原始粗糙型脂多糖或含有大肠杆菌O111杂多糖的脂多糖所表现出的水平要高得多。重组脂多糖的免疫活性与含有甘露糖同聚物的野生型脂多糖的免疫活性一样强。重组脂多糖表现出了含有甘露糖同聚物的野生型脂多糖的特征活性。脂多糖多克隆激活B细胞和产生细胞因子的能力似乎与甘露糖同聚物的存在无关。因此，有人提出，在各种脂多糖A活性中，O - 特异性多糖中的甘露糖同聚物可能专门增强抗补体活性、佐剂活性和局部淋巴结肿大活性。