Geier S A, Gürtler L, Klauss V, Mueller A, Bader L, Eberle J, Bogner J J, Kronawitter U, Goebel F D, Lund O E
Augenklinik, Universität München.
Klin Monbl Augenheilkd. 1992 Sep;201(3):164-8. doi: 10.1055/s-2008-1045886.
Reported data on the isolation of the human immunodeficiency virus type 1 (HIV-1) from tears are controversial. The purpose of the study was to try to isolate HIV-1 from tears in a large sample of HIV-1-positive patients at different stages of infection. 53 tear samples were obtained from 50 patients. Additionally isolation of HIV-1 from peripheral blood lymphocytes (PBL) was attempted. HIV-1 was isolated from none (= 0%) of the 53 tear samples. Isolation from PBL was successful depending on absolute CD4+ lymphocyte count and Walter Reed staging (Walter Reed stage 6: 83%; stage 2 to 5: 11%; p less than 0.0001). Treatment with zidovudine was not related to the frequency of HIV-1 isolation. These results suggest that tears of patients infected with HIV-1 contain low or no quantities of tissue-culture-infectious units of HIV-1. Nosocomial infection with HIV-1 from tears appears to be unlikely. The known precautions for the prevention of spread of viral disease in ophthalmological practice are sufficient and should be strictly followed.
关于从眼泪中分离出1型人类免疫缺陷病毒（HIV-1）的报告数据存在争议。本研究的目的是尝试从处于不同感染阶段的大量HIV-1阳性患者的眼泪中分离出HIV-1。从50名患者中获取了53份眼泪样本。此外，还尝试从外周血淋巴细胞（PBL）中分离HIV-1。53份眼泪样本中无一（=0%）分离出HIV-1。从PBL中分离成功与否取决于绝对CD4 +淋巴细胞计数和沃尔特·里德分期（沃尔特·里德6期：83%；2至5期：11%；p小于0.0001）。齐多夫定治疗与HIV-1分离频率无关。这些结果表明，感染HIV-1的患者眼泪中含有少量或不含HIV-1的组织培养感染单位。通过眼泪发生HIV-1医院感染似乎不太可能。眼科实践中已知的预防病毒疾病传播的预防措施是充分的，应严格遵守。
