Warner J O
Arch Dis Child. 1976 Dec;51(12):905-11. doi: 10.1136/adc.51.12.905.
Sixty-nine children with moderately severe perennial asthma were submitted to bronchial provocation tests using aqueous extracts of Dermatophagoides pteronyssinus (house dust mite). 60 (87%) had immediate positive reactions. 73% also had late reactions occurring 4 to 8 hours after the challenge. A significant correlation was found between frequent attacks of asthma in the year before bronchial challange and the occurrence of late reactions. The late reaction was more prolonged and severe than the immediate reaction. The changes in lung mechanics during a late reaction were similar to those found in severe naturally occurring asthma. The possible relevance of the late reaction in antigen-induced asthma is discussed.
69名患有中度严重常年性哮喘的儿童接受了使用屋尘螨提取物进行的支气管激发试验。60名（87%）有即刻阳性反应。73%的儿童在激发试验后4至8小时出现迟发反应。在支气管激发试验前一年中哮喘频繁发作与迟发反应的发生之间发现有显著相关性。迟发反应比即刻反应更持久、更严重。迟发反应期间肺力学的变化与严重自然发生的哮喘中发现的变化相似。讨论了迟发反应在抗原诱导性哮喘中的可能相关性。
