Desai N P, Hossainy S F, Hubbell J A
Department of Chemical Engineering, University of Texas, Austin 78712-1062.
Biomaterials. 1992;13(7):417-20. doi: 10.1016/0142-9612(92)90160-p.
Polyethylene terephthalate films were surface-modified with polyethylene oxide (18,500 g/mol) using a solution technique described previously. These films were investigated for their resistance to bacterial adhesion. Three bacterial strains most commonly associated with implant infections, Staphylococcus epidermidis, Staphylococcus aureus and Pseudomonas aeruginosa, were cultured in tryptic soya broth, human plasma and human serum on the polymeric substrates. Significant reductions (between 70 and 95%) in adherent bacteria were observed on the polyethylene oxide-modified substrates compared to the untreated control polyethylene terephthalate. Surface modification with polyethylene oxide may reduce the risk of implant-associated infections. Plasma fibrinogen was observed to play an important role in the adhesion of all three of these species on both the polyethylene oxide-modified and control polyethylene terephthalate materials.
采用先前描述的溶液技术，用聚环氧乙烷（18,500 g/mol）对聚对苯二甲酸乙二酯薄膜进行表面改性。对这些薄膜的抗细菌粘附性进行了研究。将三种最常与植入物感染相关的细菌菌株，即表皮葡萄球菌、金黄色葡萄球菌和铜绿假单胞菌，在胰蛋白胨大豆肉汤、人血浆和人血清中，在聚合物基质上进行培养。与未处理的对照聚对苯二甲酸乙二酯相比，在聚环氧乙烷改性的基质上观察到粘附细菌显著减少（70%至95%）。用聚环氧乙烷进行表面改性可能会降低植入物相关感染的风险。观察到血浆纤维蛋白原在这三种细菌在聚环氧乙烷改性和对照聚对苯二甲酸乙二酯材料上的粘附中都起着重要作用。
