Strawbridge W J, Kaplan G A, Camacho T, Cohen R D
Human Population Laboratory, California Public Health Foundation, Berkeley 94704.
J Am Geriatr Soc. 1992 Aug;40(8):799-806. doi: 10.1111/j.1532-5415.1992.tb01852.x.
To examine changes in functional status over time by age, gender, and ethnicity in a representative sample of older persons.
Six-year prospective cohort study.
Alameda County, California.
508 persons 65 years old and older at baseline in 1984.
Activities of daily living (ADL) dependence, mobility impairment, and functioning on an 18-item scale.
The prevalence of ADL dependence and mobility impairment at baseline increased with age, while function decreased. Particularly striking differences occurred for those 80 and older. Changes in function over the 6-year follow-up showed a similar pattern. While death rates for males were higher, females had poorer initial functioning, and surviving females declined more than surviving males. The incidence of ADL dependence and mobility impairment during follow-up was similar for males and females, although females survived longer with incident disability than did males. Blacks had poorer baseline functioning, more ADL dependence and mobility impairment, and declined more than non-Blacks during follow-up. Some of the baseline difference in function between Blacks and non-Blacks was due to higher rates of chronic illness and co-morbidity. In spite of the general downward trend in functioning over the 6 years, 13% of the males and 20% of the females improved.
Age-related changes in function for older persons are complex and result in much heterogeneity. Clarifying the reasons for such heterogeneity is an important and challenging area of research.
在一个具有代表性的老年人群样本中,研究功能状态随时间推移在年龄、性别和种族方面的变化。
为期六年的前瞻性队列研究。
加利福尼亚州阿拉米达县。
1984年基线时年龄在65岁及以上的508人。
日常生活活动(ADL)依赖、行动能力受损以及基于18项量表的功能状况。
基线时ADL依赖和行动能力受损的患病率随年龄增长而增加,而功能则下降。80岁及以上人群的差异尤为显著。在6年的随访中,功能变化呈现出类似的模式。虽然男性死亡率较高,但女性初始功能较差,且存活的女性比存活的男性下降得更多。随访期间,男性和女性ADL依赖和行动能力受损的发生率相似,尽管女性在出现残疾后存活的时间比男性长。黑人的基线功能较差,ADL依赖和行动能力受损更多,且在随访期间比非黑人下降得更多。黑人和非黑人在功能上的一些基线差异是由于慢性病和合并症的发生率较高。尽管在这6年中功能总体呈下降趋势,但仍有13%的男性和20%的女性功能得到改善。
老年人与年龄相关的功能变化很复杂,导致了很大的异质性。阐明这种异质性的原因是一个重要且具有挑战性的研究领域。