Li L, Teale A, Bensaid A, Dunlap S, Dietz A B, Womack J E
Department of Veterinary Pathobiology, Texas A&M University, College Station 77843.
Immunogenetics. 1992;36(4):224-9. doi: 10.1007/BF00215052.
Bovine genes encoding T-cell receptor, CD3, and CD8 molecules have been mapped to syntenic groups using bovine x rodent hybrid somatic cells. T-cell receptor alpha and delta chains were assigned to bovine syntenic group U5, and the beta and gamma genes were syntenic with each other and with markers on U13. CD3E and CD3D genes were syntenic with each other and located to bovine syntenic group U19. CD8 was most concordant with markers of syntenic group U16, although the concordancy was only 85% and the assignment must be regarded as tentative. The comparative gene maps of human chromosome 7, bovine syntenic group U13, and mouse chromosomes 6 and 13 suggest extensive evolutionary conservation.
利用牛与啮齿动物的杂交体细胞，已将编码T细胞受体、CD3和CD8分子的牛基因定位到同线群。T细胞受体α链和δ链被定位到牛同线群U5，β链和γ基因彼此同线，且与U13上的标记同线。CD3E和CD3D基因彼此同线，位于牛同线群U19。CD8与同线群U16的标记一致性最高，尽管一致性仅为85%，该定位必须视为暂定。人类7号染色体、牛同线群U13以及小鼠6号和13号染色体的比较基因图谱表明存在广泛的进化保守性。
