Mayberg H S, Starkstein S E, Peyser C E, Brandt J, Dannals R F, Folstein S E
Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, MD.
Neurology. 1992 Sep;42(9):1791-7. doi: 10.1212/wnl.42.9.1791.
We measured regional cerebral glucose metabolism using 2-[18F]-fluoro-2-deoxy-D-glucose and positron emission tomography in depressed and nondepressed patients with early Huntington's disease (HD), compared with appropriately matched controls. Caudate, putamen, and cingulate metabolism was significantly lower in patients with HD than in control subjects, independent of mood state. Orbital frontal-inferior prefrontal cortex hypometabolism, however, differentiated depressed patients from both nondepressed patients and normal controls. These findings implicate selective dysfunction of the paralimbic regions of the frontal lobes in the mood disorder of HD. The metabolic pattern is similar to that in depression associated with Parkinson's disease, suggesting that the integrity of pathways linking paralimbic frontal cortex and the basal ganglia may be integral to the normal regulation of mood.
我们使用2-[18F]-氟-2-脱氧-D-葡萄糖和正电子发射断层扫描技术，对患有早期亨廷顿舞蹈症（HD）的抑郁和非抑郁患者进行了局部脑葡萄糖代谢测量，并与相匹配的对照组进行了比较。HD患者的尾状核、壳核和扣带回代谢显著低于对照组，且与情绪状态无关。然而，眶额-额下回皮质代谢减退使抑郁患者与非抑郁患者及正常对照组区分开来。这些发现表明额叶边缘旁区域的选择性功能障碍与HD的情绪障碍有关。这种代谢模式与帕金森病伴发的抑郁症相似，提示连接边缘旁额叶皮质和基底神经节的通路完整性可能对情绪的正常调节至关重要。
