Dom P, Haesebrouck F
Laboratory of Veterinary Bacteriology, Faculty of Veterinary Medicine, University of Gent, Belgium.
Zentralbl Veterinarmed B. 1992 Jun;39(4):303-6. doi: 10.1111/j.1439-0450.1992.tb01173.x.
The virulence of a NAD-independent Actinobacillus pleuropneumoniae serotype 2 strain and NAD-dependent serotype 2, 3 and 9 strains was compared under experimental conditions. Hysterectomy-derived piglets were inoculated endobronchially with 50-500 cfu of these strains. All 23 piglets inoculated with the NAD-dependent strains developed acute disease within 12 hours post inoculation. Twenty-two of these piglets died within 24 hours after the first clinical signs. Three of nine piglets inoculated with the NAD-independent strain did not develop clinical disease. In the other six piglets, disease signs were similar as in the piglets inoculated with the NAD-dependent strains. No differences in clinical disease were observed between colostrum deprived piglets and piglets that obtained colostrum from a SPF sow.
在实验条件下，比较了一株不依赖烟酰胺腺嘌呤二核苷酸（NAD）的胸膜肺炎放线杆菌2型菌株与依赖NAD的2型、3型和9型菌株的毒力。用这些菌株的50 - 500个菌落形成单位（cfu）经支气管内接种子宫切除术后获得的仔猪。所有接种依赖NAD菌株的23头仔猪在接种后12小时内均出现急性疾病。其中22头仔猪在出现首次临床症状后24小时内死亡。接种不依赖NAD菌株的9头仔猪中有3头未出现临床疾病。在其他6头仔猪中，疾病症状与接种依赖NAD菌株的仔猪相似。未观察到初乳剥夺仔猪与从无特定病原体（SPF）母猪获得初乳的仔猪在临床疾病方面存在差异。
