甲磺替苯胺的降眼压作用。
Ocular hypotensive effects of medifoxamine.
作者信息
Saleh S, Turner P
机构信息
Department of Clinical Pharmacology, St Bartholomew's Hospital, London.
出版信息
Br J Clin Pharmacol. 1992 Sep;34(3):269-71. doi: 10.1111/j.1365-2125.1992.tb04136.x.
Abstract
Medifoxamine is a novel monoamine re-uptake inhibiting antidepressive drug which preferentially inhibits dopamine reuptake. In human volunteer studies it has been found to reduce significantly intraocular pressure after single oral doses of 300-1000 mg, and to produce a small but statistically significant miosis. Its maximal ocular hypotensive action was less than that of oral timolol 20 mg.
摘要
美地沙明是一种新型单胺再摄取抑制性抗抑郁药物，它优先抑制多巴胺再摄取。在人体志愿者研究中发现，单次口服300 - 1000毫克后，它能显著降低眼压，并产生轻微但具有统计学意义的瞳孔缩小。其最大降眼压作用小于口服20毫克噻吗洛尔的作用。
相似文献
1
Ocular hypotensive effects of medifoxamine.甲磺替苯胺的降眼压作用。
Br J Clin Pharmacol. 1992 Sep;34(3):269-71. doi: 10.1111/j.1365-2125.1992.tb04136.x.
2
The pharmacokinetics and pharmacodynamics of medifoxamine after oral administration in healthy elderly volunteers.美多沙明在健康老年志愿者口服给药后的药代动力学和药效学
Eur J Clin Pharmacol. 1994;46(2):163-6. doi: 10.1007/BF00199882.
3
Effect of topical indomethacin and timolol maleate on intraocular pressure in normal subjects.局部应用吲哚美辛和马来酸噻吗洛尔对正常受试者眼压的影响。
Am J Ophthalmol. 1985 May 15;99(5):576-8. doi: 10.1016/s0002-9394(14)77962-0.
4
Dose response of oral timolol combined with adrenaline.口服噻吗洛尔联合肾上腺素的剂量反应。
Br J Ophthalmol. 1982 Apr;66(4):242-6. doi: 10.1136/bjo.66.4.242.
5
Indomethacin does not attenuate the ocular hypotensive effect of timolol.吲哚美辛不会减弱噻吗洛尔的降眼压作用。
Br J Clin Pharmacol. 1985 Apr;19(4):523-4. doi: 10.1111/j.1365-2125.1985.tb02680.x.
6
Tolerability and kinetics of intravenous medifoxamine in healthy volunteers.
Int Clin Psychopharmacol. 1990 Apr;5(2):97-102. doi: 10.1097/00004850-199004000-00003.
7
[Effect of carteolol and timolol eyedrops on the pressure tolerance of the optic nerve head].[卡替洛尔和噻吗洛尔滴眼液对视神经乳头压力耐受性的影响]
Ophthalmologica. 1989;198(2):64-77. doi: 10.1159/000309961.
8
Dopamine-2 receptor blockade does not affect the ocular hypotensive action of timolol.多巴胺-2受体阻断并不影响噻吗洛尔的降眼压作用。
Br J Ophthalmol. 1988 Aug;72(8):598-600. doi: 10.1136/bjo.72.8.598.
9
The effect of a single oral dose of pergolide on intraocular pressure and pupil diameter.单次口服培高利特对眼压和瞳孔直径的影响。
Br J Clin Pharmacol. 1989 Sep;28(3):263-8. doi: 10.1111/j.1365-2125.1989.tb05425.x.
10
Ocular and cardiovascular response to topical carteolol 2% and timolol 0.5% in healthy volunteers.健康志愿者对局部应用2%卡替洛尔和0.5%噻吗洛尔的眼部及心血管反应。
Br J Ophthalmol. 1988 Feb;72(2):101-3. doi: 10.1136/bjo.72.2.101.
本文引用的文献
1
Bromocriptine eyedrops lower intraocular pressure without affecting prolactin levels.溴隐亭滴眼液可降低眼压，且不影响催乳素水平。
Lancet. 1984 Feb 4;1(8371):287-8. doi: 10.1016/s0140-6736(84)90162-4.
2
A new tonometer system.
Am J Optom Arch Am Acad Optom. 1972 Aug;49(8):646-60. doi: 10.1097/00006324-197208000-00005.
3
Stimulation of dopamine receptors (type 2) lowers human intraocular pressure.刺激多巴胺2型受体可降低人眼内压。
Br J Ophthalmol. 1985 Dec;69(12):909-10. doi: 10.1136/bjo.69.12.909.
4
The effects of lisuride, terguride and bromocriptine on intraocular pressure (IOP).利苏瑞肽、特古瑞肽和溴隐亭对眼压（IOP）的影响。
Br J Clin Pharmacol. 1989 Feb;27(2):159-63. doi: 10.1111/j.1365-2125.1989.tb05346.x.
5
A comparison of the ocular hypotensive effect of 0.025% bromocriptine and 0.25% timolol eye drops in normal human volunteers.0.025%溴隐亭滴眼液与0.25%噻吗洛尔滴眼液对正常人类志愿者的降眼压效果比较。
Br J Clin Pharmacol. 1989 Oct;28(4):443-7. doi: 10.1111/j.1365-2125.1989.tb03525.x.
6
Antagonism by domperidone of the ocular hypotensive effect of pergolide.多潘立酮对培高利特眼压降低作用的拮抗作用。
Eur J Clin Pharmacol. 1990;38(5):461-3. doi: 10.1007/BF02336684.
7
Intraocular pressure increases with fenoldopam, but not nitroprusside, in hypertensive humans.在高血压患者中，使用非诺多泮会导致眼压升高，但使用硝普钠则不会。
Clin Pharmacol Ther. 1991 Mar;49(3):285-93. doi: 10.1038/clpt.1991.30.
Zotero 插件