Avill R, Mangnall Y F, Bird N C, Brown B H, Barber D C, Seagar A D, Johnson A G, Read N W
Gastroenterology. 1987 Apr;92(4):1019-26.
Applied potential tomography is a new, noninvasive technique that yields sequential images of the resistivity of gastric contents after subjects have ingested a liquid or semisolid meal. This study validates the technique as a means of measuring gastric emptying. Experiments in vitro showed an excellent correlation between measurements of resistivity and either the square of the radius of a glass rod or the volume of water in a spherical balloon when both were placed in an oval tank containing saline. Altering the lateral position of the rod in the tank did not alter the values obtained. Images of abdominal resistivity were also directly correlated with the volume of air in a gastric balloon. Profiles of gastric emptying of liquid meals obtained using applied potential tomography were very similar to those obtained using scintigraphy or dye dilution techniques, provided that acid secretion was inhibited by cimetidine. Profiles of emptying of a mashed potato meal using applied potential tomography were also very similar to those obtained by scintigraphy. Measurements of the emptying of a liquid meal from the stomach were reproducible if acid secretion was inhibited by cimetidine. Thus, applied potential tomography is an accurate and reproducible method of measuring gastric emptying of liquids and particulate food. It is inexpensive, well tolerated, easy to use, and ideally suited for multiple studies in patients, even those who are pregnant.
应用电位断层扫描是一种新的非侵入性技术，在受试者摄入液体或半固体食物后，可生成胃内容物电阻率的连续图像。本研究验证了该技术作为测量胃排空的一种方法。体外实验表明，当将玻璃棒半径的平方或球形气球中的水量置于装有盐水的椭圆形水箱中时，电阻率测量值与它们之间具有极好的相关性。改变棒在水箱中的横向位置不会改变所获得的值。腹部电阻率图像也与胃气球中的空气量直接相关。如果用西咪替丁抑制胃酸分泌，那么使用应用电位断层扫描获得的液体食物胃排空曲线与使用闪烁扫描法或染料稀释技术获得的曲线非常相似。使用应用电位断层扫描获得的土豆泥食物排空曲线也与闪烁扫描法获得的曲线非常相似。如果用西咪替丁抑制胃酸分泌，从胃中排空液体食物的测量结果是可重复的。因此，应用电位断层扫描是一种准确且可重复的测量液体和颗粒食物胃排空的方法。它价格低廉，耐受性好，易于使用，非常适合对患者进行多次研究，甚至适用于孕妇。
