Saeger W
Virchows Arch A Pathol Anat Histol. 1977 Jan 20;372(4):299-314. doi: 10.1007/BF00432405.
98 biopsies of the paraadenomatous adenohypophysis in acromegaly, galactorrhea combined acromegaly, isolated galactorrhea, hypothalamic-hypopphysial Cushing's disease. Nelson's syndrome, and in nonfunctional adenomas were studied by light microscopic methods in order to find evidence for a possible hyperplasiogenic origin of the different types of adenomas. It was hoped that the numerical relations and structures of hypophysial cells might provide significant information. Nodular ACTH cell-hyperplasia was found frequently apart from ACTH cell-tumors in Cushing's disease and Nelson's syndrome and on this basis we suggest that the adenomas in both diseases arise from hyperplasia. During their further development these adenomas seem to become autonomous, since the number of paraadenomatous ACTH cells decreased in bigger tumors. Some of the cases with isolated galactorrhea showed hyperplasia of acidophil and chromophobe cells in the paraadenomatous adenohypophysis. It can thus be assumed that porlactin cell-tumors also develop from prolactin cell-hyperplasia. Both the adenomas and the nonfunctional tumors in acromegaly seem to grow autonomously from the beginning, since paraadenomatous hyperplasia is seldom seen.
为了寻找不同类型腺瘤可能的增生起源证据，采用光学显微镜方法研究了98例肢端肥大症、溢乳合并肢端肥大症、单纯溢乳、下丘脑 - 垂体性库欣病、尼尔森综合征以及无功能腺瘤患者的腺垂体腺瘤旁组织活检标本。希望垂体细胞的数量关系和结构能提供重要信息。在库欣病和尼尔森综合征中，除了促肾上腺皮质激素（ACTH）细胞肿瘤外，经常发现结节性ACTH细胞增生，基于此我们认为这两种疾病中的腺瘤均起源于增生。在腺瘤进一步发展过程中，它们似乎变得自主，因为在较大肿瘤中腺瘤旁ACTH细胞数量减少。一些单纯溢乳病例显示腺瘤旁腺垂体嗜酸性和嫌色细胞增生。因此可以推测催乳素细胞瘤也由催乳素细胞增生发展而来。肢端肥大症中的腺瘤和无功能肿瘤似乎从一开始就自主生长，因为很少见到腺瘤旁增生。
