“正常”受试者及接受双硫仑治疗的酗酒受试者的血液二硫化碳浓度。
Blood concentration of carbon disulphide in "normal" subjects and in alcoholic subjects treated with disulfiram.
作者信息
Brugnone F, Maranelli G, Zotti S, Zanella I, De Paris P, Caroldi S, Betta A
机构信息
Istituto di Medicina del Lavoro, Università di Verona, Italy.
出版信息
Br J Ind Med. 1992 Sep;49(9):658-63. doi: 10.1136/oem.49.9.658.
Assay of free and acid labile carbon disulphide (free and total CS2 respectively) in human blood was performed by gas chromatography/spectrometry. The method used a large dynamic head space volume and a "cryogenic trap". Blood CS2 concentration was measured in 42 subjects not occupationally exposed to CS2 (group A) and in 11 alcoholic subjects (group B) treated with disulfiram. Free CS2 concentration showed a mean value of 261 ng/l in the 42 subjects in group A and 9482 ng/l in eight subjects of group B. Total CS2 concentration was 897 ng/l and 40,084 ng/l in groups A and B respectively. Differences between the groups were highly significant for concentrations of both free and total CS2. Total CS2 concentration was about four times as high as free CS2 concentration in both groups. A significant correlation was found between free and total CS2 concentration both in group A and in group B. In the alcoholic subjects (group B), blood concentrations of both free and total CS2 were related to time of sampling after treatment with disulfiram.
采用气相色谱/光谱法对人体血液中的游离及酸不稳定二硫化碳（分别为游离和总二硫化碳）进行测定。该方法采用了大动态顶空体积和“低温捕集阱”。对42名未职业性接触二硫化碳的受试者（A组）和11名接受双硫仑治疗的酗酒受试者（B组）测定了血液中二硫化碳浓度。A组42名受试者的游离二硫化碳浓度平均值为261 ng/l，B组8名受试者的游离二硫化碳浓度平均值为9482 ng/l。A组和B组的总二硫化碳浓度分别为897 ng/l和40,084 ng/l。两组间游离和总二硫化碳浓度差异均极显著。两组中总二硫化碳浓度均约为游离二硫化碳浓度的四倍。A组和B组中游离和总二硫化碳浓度之间均存在显著相关性。在酗酒受试者（B组）中，游离和总二硫化碳的血液浓度均与双硫仑治疗后的采样时间有关。
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