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Comparative in vivo mutagenicity testing by SCE and micronucleus induction in mouse bone marrow.

作者信息

Bauknecht T, Vogel W, Bayer U, Wild D

出版信息

Hum Genet. 1977 Mar 14;35(3):299-307. doi: 10.1007/BF00446622.

DOI:10.1007/BF00446622
PMID:139356
Abstract

The treatment of mice with repeated injections of BUdR and FUdR allows for the demonstration of differentially stained metaphases from bone marrow after FPG (fluorescence plus Giemsa; Perry and Wolff, 1974) treatment. Thus, it is possible to determine the number of SCE's under in vivo conditions, which appears as a very promising system for mutagenicity testing. We studied the response of this system in comparison to the micronucleus test using six mutagenic agents: triaziquone, cyclophosphamide (CP), dimethylphenyltriazene (PDMT), methylnitronitrosoguandine (MNNG), dimethylnitrosamine (DMNA), and diethylnitrosamine (DENA). With the exception of MNNG and DENA, all these agents induce both, SCE and micronuclei, MNNG and and DENA being ineffective in both systems. The most potent SCE-inducing agent was triaziquone, followed by PDMT, CP, and DMNA. The quantitative comparison indicates that SCE are induced at 1/10-1/100 of the concentrations which are required for the detection of micronuclei.

摘要

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本文引用的文献

1
Sister chromatid exchanges induced in Chinese hamster cells by UV irradiation of different stages of the cell cycle: the necessity for cells to pass through S.不同细胞周期阶段紫外线照射诱导中国仓鼠细胞姐妹染色单体交换：细胞通过S期的必要性
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致突变性试验中的姐妹染色单体交换（SCE）和染色体结构畸变
Hum Genet. 1981;58(3):235-54. doi: 10.1007/BF00294917.
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Cytogenetic effects of paraoxon and methyl-parathion on cultured human lymphocytes: SCE, clastogenic activity and cell cycle delay.对氧磷和甲基对硫磷对培养的人淋巴细胞的细胞遗传学效应：姐妹染色单体交换、致断裂活性和细胞周期延迟。
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Chromosoma. 1974;48(4):355-60. doi: 10.1007/BF00290992.
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[Chromatid exchanges in human mitotic cells. BUDR Treatment and bichromatic fluorescence by aridine orange (author's transl)].[人类有丝分裂细胞中的染色单体交换。BUDR处理及吖啶橙双色荧光法（作者译）]
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7
New Giemsa method for the differential staining of sister chromatids.用于姐妹染色单体鉴别染色的新吉姆萨方法。
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Nature. 1976 Apr 1;260(5550):449-51. doi: 10.1038/260449a0.