人类白细胞检测系统。VI. 利用姐妹染色单体交换作为诱变活性的可能指标。
The human leukocyte test system. VI. The use of sister chromatid exchanges as possible indicators for mutagenic activities.
作者信息
Beek B, Obe G
出版信息
Humangenetik. 1975 Sep 10;29(2):127-34. doi: 10.1007/BF00430349.
PMID:1176134
Abstract
The trifunctional alkylating chemical mutagen trenimon increases the frequency of sister chromatid exchanges in human leukocyte chromosomes in vitro, as revealed by a BUdR-Giemsa method. Treatment with lead acetate exhibited negative results in this respect. The use of sister chromatid exchanges as possible indicators for mutagenic activities is discussed.
摘要
三功能烷基化化学诱变剂三乙撑密胺（trenimon）在体外可增加人类白细胞染色体中姐妹染色单体交换的频率，这是通过5-溴脱氧尿苷-吉姆萨（BUdR-Giemsa）方法揭示的。在这方面，醋酸铅处理显示出阴性结果。本文讨论了将姐妹染色单体交换用作诱变活性可能指标的用途。
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