Holmes C A
AIDS Education Project, California College of Podiatric Medicine, San Francisco.
Clin Podiatr Med Surg. 1992 Oct;9(4):939-49.
Taken together, studies of seroconversion, exposure incidents, and compliance with Universal Precautions Policy help researchers understand the risks to health care workers of occupationally acquired HIV infection. The seroconversion studies show that the risk of infection is low (1 in 250) even when the incident is a percutaneous exposure to blood from a known HIV-positive patient. When the exposure is to blood from a patient whose HIV-status is unknown, or if the exposure is not through the skin, or if the exposure is to a body substance other than blood, the risk is considerably lower. The studies of exposure incidents show that for most health care workers, percutaneous exposures to blood are infrequent. Studies of compliance with Universal Precautions Policy show that exposure incidents that do occur can be prevented nearly half the time. The risk of patient-to-provider transmission of HIV is small but not completely negligible. This small risk can be made even smaller by adhering to recommended infection control guidelines, but it cannot be eliminated completely. Although most health care workers enter the medical field accepting that their work may expose them to infectious agents, there is still a desire for risk-free practice. Achieving an entirely risk-free practice is probably impossible; it is certainly not within reach today. For the foreseeable future, the only reasonable course is to fully understand the risks, to enter into practice psychologically prepared to accept these risks, and to practice in a way that minimizes exposures without compromising patient care.
综合来看,血清转化研究、暴露事件研究以及对通用预防措施政策的依从性研究有助于研究人员了解医护人员职业性感染艾滋病毒的健康风险。血清转化研究表明,即使事件是经皮暴露于已知艾滋病毒阳性患者的血液中,感染风险也很低(250分之一)。当暴露于艾滋病毒状况未知患者的血液中,或者暴露不是通过皮肤,或者暴露于血液以外的身体物质时,风险则要低得多。暴露事件研究表明,对于大多数医护人员来说,经皮暴露于血液的情况并不常见。对通用预防措施政策依从性的研究表明,确实发生的暴露事件近一半是可以预防的。艾滋病毒从患者传播给医护人员的风险很小,但并非完全可以忽略不计。通过遵守推荐的感染控制指南,这种小风险可以变得更小,但无法完全消除。尽管大多数医护人员进入医疗领域时就知道他们的工作可能使他们接触到传染源,但他们仍然希望无风险地开展工作。实现完全无风险的工作可能是不可能的;在当今肯定也无法实现。在可预见的未来,唯一合理的做法是充分了解风险,在心理上做好接受这些风险的准备后进入工作,并以在不影响患者护理的情况下尽量减少暴露的方式开展工作。