Weisenburger D D
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-3135.
Cancer Res. 1992 Oct 1;52(19 Suppl):5456s-5462s; discussion 5462s-5464s.
Non-Hodgkin's lymphoma (NHL) consists of a heterogeneous group of disorders which have been difficult to study by epidemiological means in the past. However, recent advances in knowledge of the biology of NHL and improvements in its classification will greatly improve the quality of epidemiological studies in the future. Use of the Working Formulation and the current International Classification of Diseases for Oncology, along with paraffin immunohistochemistry, allow the delineation of NHL subgroups with possible etiological significance based on the biology of the disease. The collaboration of epidemiologists with expert pathologists in the design, performance, and evaluation of epidemiological studies of NHL is essential for such studies to be meaningful.
非霍奇金淋巴瘤（NHL）由一组异质性疾病组成，过去通过流行病学方法很难对其进行研究。然而，近期NHL生物学知识的进展及其分类的改进将极大地提高未来流行病学研究的质量。使用工作分类法和当前的国际肿瘤疾病分类法，结合石蜡免疫组织化学，能够根据疾病生物学特性界定出可能具有病因学意义的NHL亚组。在NHL流行病学研究的设计、实施和评估过程中，流行病学家与专业病理学家的合作对于此类研究具有意义至关重要。
