Linet M S, Pottern L M
Epidemiology and Biostatistics Program, National Cancer Institute, Rockville, Maryland 20892.
Cancer Res. 1992 Oct 1;52(19 Suppl):5468s-5473s.
Examination of risk factors that may be responsible for the increasing incidence of non-Hodgkin's lymphoma (NHL) over the past few decades would be incomplete without considering familial aggregation of hematolymphoproliferative neoplasms and the relative contributions of heredity and environment to the etiology of NHL. Reports of families with two or more NHL cases and sometimes additional members affected by other hematopoietic malignancies (multiple-case families) are summarized, as are findings from surveys and quantitative risk estimates from population-based studies of familial aggregation. The notable occurrence of various immunological abnormalities among multiple-case family members with and without NHL or related neoplasms is underscored, as is the diversity of types of other lymphoproliferative and hematopoietic malignancies among close relatives in these families. Preliminary evidence suggesting that multiple-case families may be more susceptible to certain environmental exposures is presented. An international registry of such families (particularly those identified in population-based studies) is proposed to clarify the interrelationship of genetic, familial, and environmental factors in the etiology of NHL.
如果不考虑血液淋巴增殖性肿瘤的家族聚集性以及遗传和环境对非霍奇金淋巴瘤（NHL）病因的相对贡献，那么对过去几十年中可能导致NHL发病率上升的危险因素进行研究将是不完整的。本文总结了有两例或更多例NHL病例且有时还有其他家庭成员受其他造血系统恶性肿瘤影响的家庭（多病例家庭）的报告，以及基于人群的家族聚集性研究的调查结果和定量风险估计。强调了在有或没有NHL或相关肿瘤的多病例家庭成员中各种免疫异常的显著发生，以及这些家庭近亲中其他淋巴增殖性和造血系统恶性肿瘤类型的多样性。还提出了初步证据，表明多病例家庭可能更容易受到某些环境暴露的影响。建议建立一个此类家庭（特别是在基于人群的研究中确定的家庭）的国际登记处，以阐明遗传、家族和环境因素在NHL病因中的相互关系。
